Ceramide/Sphingosine 1-Phosphate Axis as a Key Target for Diagnosis and Treatment in Alzheimer’s Disease and Other Neurodegenerative Diseases

Antía Custodia; Daniel Romaus-Sanjurjo; Marta Aramburu-Núñez; Diego Álvarez-Rafael; Laura Vázquez-Vázquez; Javier Camino-Castiñeiras; Yago Leira; Juan Manuel Pías-Peleteiro; José Manuel Aldrey; Tomás Sobrino; Alberto Ouro

doi:10.3390/ijms23158082

Ceramide/Sphingosine 1-Phosphate Axis as a Key Target for Diagnosis and Treatment in Alzheimer’s Disease and Other Neurodegenerative Diseases

Antía Custodia, Daniel Romaus-Sanjurjo, Marta Aramburu-Núñez, Diego Álvarez-Rafael, Laura Vázquez-Vázquez, Javier Camino-Castiñeiras, Yago Leira, Juan Manuel Pías-Peleteiro, José Manuel Aldrey, Tomás Sobrino, Alberto Ouro

Research output: Contribution to journal › Review article › peer-review

15 Scopus citations

Abstract

Alzheimer’s disease (AD) is considered the most prevalent neurodegenerative disease and the leading cause of dementia worldwide. Sphingolipids, such as ceramide or sphingosine 1-phosphate, are bioactive molecules implicated in structural and signaling functions. Metabolic dysfunction in the highly conserved pathways to produce sphingolipids may lead to or be a consequence of an underlying disease. Recent studies on transcriptomics and sphingolipidomics have observed alterations in sphingolipid metabolism of both enzymes and metabolites involved in their synthesis in several neurodegenerative diseases, including AD. In this review, we highlight the most relevant findings related to ceramide and neurodegeneration, with a special focus on AD.

Original language	English
Article number	8082
Journal	International Journal of Molecular Sciences
Volume	23
Issue number	15
DOIs	https://doi.org/10.3390/ijms23158082
State	Published - 1 Aug 2022
Externally published	Yes

Keywords

Alzheimer’s disease
ceramide
metabolism
sphingolipidomics
sphingolipids
sphingosine 1-phosphate
tau
β-amyloid

ASJC Scopus subject areas

Catalysis
Molecular Biology
Spectroscopy
Computer Science Applications
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry

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10.3390/ijms23158082

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Custodia, A., Romaus-Sanjurjo, D., Aramburu-Núñez, M., Álvarez-Rafael, D., Vázquez-Vázquez, L., Camino-Castiñeiras, J., Leira, Y., Pías-Peleteiro, J. M., Aldrey, J. M., Sobrino, T., & Ouro, A. (2022). Ceramide/Sphingosine 1-Phosphate Axis as a Key Target for Diagnosis and Treatment in Alzheimer’s Disease and Other Neurodegenerative Diseases. International Journal of Molecular Sciences, 23(15), Article 8082. https://doi.org/10.3390/ijms23158082

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title = "Ceramide/Sphingosine 1-Phosphate Axis as a Key Target for Diagnosis and Treatment in Alzheimer{\textquoteright}s Disease and Other Neurodegenerative Diseases",

abstract = "Alzheimer{\textquoteright}s disease (AD) is considered the most prevalent neurodegenerative disease and the leading cause of dementia worldwide. Sphingolipids, such as ceramide or sphingosine 1-phosphate, are bioactive molecules implicated in structural and signaling functions. Metabolic dysfunction in the highly conserved pathways to produce sphingolipids may lead to or be a consequence of an underlying disease. Recent studies on transcriptomics and sphingolipidomics have observed alterations in sphingolipid metabolism of both enzymes and metabolites involved in their synthesis in several neurodegenerative diseases, including AD. In this review, we highlight the most relevant findings related to ceramide and neurodegeneration, with a special focus on AD.",

keywords = "Alzheimer{\textquoteright}s disease, ceramide, metabolism, sphingolipidomics, sphingolipids, sphingosine 1-phosphate, tau, β-amyloid",

author = "Ant{\'i}a Custodia and Daniel Romaus-Sanjurjo and Marta Aramburu-N{\'u}{\~n}ez and Diego {\'A}lvarez-Rafael and Laura V{\'a}zquez-V{\'a}zquez and Javier Camino-Casti{\~n}eiras and Yago Leira and P{\'i}as-Peleteiro, {Juan Manuel} and Aldrey, {Jos{\'e} Manuel} and Tom{\'a}s Sobrino and Alberto Ouro",

note = "Publisher Copyright: {\textcopyright} 2022 by the authors.",

year = "2022",

month = aug,

day = "1",

doi = "10.3390/ijms23158082",

language = "English",

volume = "23",

journal = "International Journal of Molecular Sciences",

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Custodia, A, Romaus-Sanjurjo, D, Aramburu-Núñez, M, Álvarez-Rafael, D, Vázquez-Vázquez, L, Camino-Castiñeiras, J, Leira, Y, Pías-Peleteiro, JM, Aldrey, JM, Sobrino, T & Ouro, A 2022, 'Ceramide/Sphingosine 1-Phosphate Axis as a Key Target for Diagnosis and Treatment in Alzheimer’s Disease and Other Neurodegenerative Diseases', International Journal of Molecular Sciences, vol. 23, no. 15, 8082. https://doi.org/10.3390/ijms23158082

Ceramide/Sphingosine 1-Phosphate Axis as a Key Target for Diagnosis and Treatment in Alzheimer’s Disease and Other Neurodegenerative Diseases. / Custodia, Antía; Romaus-Sanjurjo, Daniel; Aramburu-Núñez, Marta et al.
In: International Journal of Molecular Sciences, Vol. 23, No. 15, 8082, 01.08.2022.

Research output: Contribution to journal › Review article › peer-review

TY - JOUR

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AU - Custodia, Antía

AU - Romaus-Sanjurjo, Daniel

AU - Aramburu-Núñez, Marta

AU - Álvarez-Rafael, Diego

AU - Vázquez-Vázquez, Laura

AU - Camino-Castiñeiras, Javier

AU - Leira, Yago

AU - Pías-Peleteiro, Juan Manuel

AU - Aldrey, José Manuel

AU - Sobrino, Tomás

AU - Ouro, Alberto

PY - 2022/8/1

Y1 - 2022/8/1

N2 - Alzheimer’s disease (AD) is considered the most prevalent neurodegenerative disease and the leading cause of dementia worldwide. Sphingolipids, such as ceramide or sphingosine 1-phosphate, are bioactive molecules implicated in structural and signaling functions. Metabolic dysfunction in the highly conserved pathways to produce sphingolipids may lead to or be a consequence of an underlying disease. Recent studies on transcriptomics and sphingolipidomics have observed alterations in sphingolipid metabolism of both enzymes and metabolites involved in their synthesis in several neurodegenerative diseases, including AD. In this review, we highlight the most relevant findings related to ceramide and neurodegeneration, with a special focus on AD.

AB - Alzheimer’s disease (AD) is considered the most prevalent neurodegenerative disease and the leading cause of dementia worldwide. Sphingolipids, such as ceramide or sphingosine 1-phosphate, are bioactive molecules implicated in structural and signaling functions. Metabolic dysfunction in the highly conserved pathways to produce sphingolipids may lead to or be a consequence of an underlying disease. Recent studies on transcriptomics and sphingolipidomics have observed alterations in sphingolipid metabolism of both enzymes and metabolites involved in their synthesis in several neurodegenerative diseases, including AD. In this review, we highlight the most relevant findings related to ceramide and neurodegeneration, with a special focus on AD.

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KW - ceramide

KW - metabolism

KW - sphingolipidomics

KW - sphingolipids

KW - sphingosine 1-phosphate

KW - tau

KW - β-amyloid

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ER -

Ceramide/Sphingosine 1-Phosphate Axis as a Key Target for Diagnosis and Treatment in Alzheimer’s Disease and Other Neurodegenerative Diseases

Abstract

Keywords

ASJC Scopus subject areas

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