Cerebral palsy-trends in epidemiology and recent development in prenatal mechanisms of disease, treatment, and prevention

Moshe Stavsky, Omer Mor, Salvatore Andrea Mastrolia, Shirley Greenbaum, Nandor Gabor Than, Offer Erez

Research output: Contribution to journalReview articlepeer-review

129 Scopus citations

Abstract

Cerebral palsy (CP) is the most common motor disability in childhood. This syndrome is the manifestation of intrauterine pathologies, intrapartum complications, and the postnatal sequel, especially among preterm neonates. A double hit model theory is proposed suggesting that an intrauterine condition along with intrapartum or postnatal insult lead to the development of CP. Recent reports demonstrated that treatment during the process of preterm birth such as magnesium sulfate and postnatal modalities such as cooling may prevent or reduce the prevalence of this syndrome. Moreover, animal models demonstrated that postnatal treatment with anti-inflammatory drugs coupled with nanoparticles may affect the course of the disease in pups with neuroinflammation. This review will describe the changes in the epidemiology of this disease, the underlying prenatal mechanisms, and possible treatments that may reduce the prevalence of CP and alter the course of the disease.

Original languageEnglish
Article number21
JournalFrontiers in Pediatrics
Volume5
DOIs
StatePublished - 13 Feb 2017
Externally publishedYes

Keywords

  • Birth asphyxia
  • Cerebral palsy
  • Intrauterine infection
  • Magnesium sulfate
  • N-acetyl cysteine
  • Nanoparticles
  • Neuroinflammation
  • Progesterone

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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