Changes in amniotic fluid concentrations of prostaglandins E2 and F(2α) in women with preterm labor

M. Mazor, A. Wiznitzer, E. Maymon, J. R. Leiberman, A. Cohen

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33 Scopus citations


There is a paucity of data regarding the concentration of prostaglandins (PGs) in the amniotic fluid of women with preterm labor. The purpose of this study was to determine if preterm labor is associated with changes in amniotic fluid concentration of prostaglandins E2 and F(2α). Amniotic fluid was retrieved by transabdominal amniocentesis from women with preterm labor and intact membranes. Patients were classified into three groups according to the response to tocolysis and the presence or absence of intra-amniotic infection. PGE2 and PGF(2α) were measured using specific and sensitive RIA kits. Amniotic fluid concentrations of PGE2 and PGF(2α) were significantly higher in women with preterm labor and intra-amniotic infection than in women without infection, regardless of the response to tocolysis. These data suggest that both PGs are involved in the mechanisms of preterm labor and may have prognostic value.

Original languageEnglish
Pages (from-to)425-428
Number of pages4
JournalIsrael Journal of Medical Sciences
Issue number8
StatePublished - 1 Jan 1990
Externally publishedYes


  • amniotic fluid
  • intra-amniotic infection
  • preterm labor
  • prostaglandins
  • tocolysis


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