Changes in interleukin-1 β and soluble interleukin-2 receptor levels in csf and serum of schizophrenic patients

Vivian Barak, Benjamin Nisman, Isaac Roisman, Yoram Barak, Joseph Levine

Research output: Contribution to journalArticlepeer-review

95 Scopus citations


Some evidence points towards a possible autoimmune role in the aetiology of schizophrenia. Experimental findings provide contradictory results regarding abnormalities in cytokine production in this disorder. In the present study we tested the production of cytokines in CSF and serum in 16 schizophrenic patients and 10 healthy controls (tumor necrosis factor a - TNFα; interleukins IL-1β, IL-2, IL-6, soluble IL-2 receptor). Cytokine levels were evaluated by radio-actively-labeled antibodies (IL-1β, IL-2, IL-6), by enzyme-linked immunoassay (TNF) and by a sandwich enzyme immunoassay (soluble IL-2 receptor). No significant differences were found in either CSF fluid or serum levels of TNF and IL-2 or IL-6. Interleukin-1β was significantly decreased in patients' CSF and serum as compared to controls. Soluble interleukin-2 receptor levels were decreased in CSF of patients, but highly increased in their serum in comparison with controls. Changes in various cytokine levels in CSF fluid and serum of schizophrenic patients probably reflect interrelated processes of growth, degeneration or neuroimmunological abnormalities, which may all play a role in the pathophysiology of schizophrenia. The present study supports evidence for change in immune activation, probably of peripheral origin, in schizophrenic patients.

Original languageEnglish
Pages (from-to)61-70
Number of pages10
JournalJournal of Basic and Clinical Physiology and Pharmacology
Issue number1
StatePublished - 1 Jan 1995
Externally publishedYes

ASJC Scopus subject areas

  • Physiology
  • Pharmacology
  • Drug Discovery


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