TY - JOUR
T1 - Changes in interleukin-1 β and soluble interleukin-2 receptor levels in csf and serum of schizophrenic patients
AU - Barak, Vivian
AU - Nisman, Benjamin
AU - Roisman, Isaac
AU - Barak, Yoram
AU - Levine, Joseph
N1 - Funding Information:
Sixteen male patients admitted to our acute psychiatric unit who met DSM-III-R diagnostic criteria for schizophrenia were studied along with 10 healthy subjects who were matched for sex and age. All 26 subjects gave their informed consent for participation in a research project approved by the Ministry of Health's Helsinki Committee, of which this cytokine study formed a part.
PY - 1995/1/1
Y1 - 1995/1/1
N2 - Some evidence points towards a possible autoimmune role in the aetiology of schizophrenia. Experimental findings provide contradictory results regarding abnormalities in cytokine production in this disorder. In the present study we tested the production of cytokines in CSF and serum in 16 schizophrenic patients and 10 healthy controls (tumor necrosis factor a - TNFα; interleukins IL-1β, IL-2, IL-6, soluble IL-2 receptor). Cytokine levels were evaluated by radio-actively-labeled antibodies (IL-1β, IL-2, IL-6), by enzyme-linked immunoassay (TNF) and by a sandwich enzyme immunoassay (soluble IL-2 receptor). No significant differences were found in either CSF fluid or serum levels of TNF and IL-2 or IL-6. Interleukin-1β was significantly decreased in patients' CSF and serum as compared to controls. Soluble interleukin-2 receptor levels were decreased in CSF of patients, but highly increased in their serum in comparison with controls. Changes in various cytokine levels in CSF fluid and serum of schizophrenic patients probably reflect interrelated processes of growth, degeneration or neuroimmunological abnormalities, which may all play a role in the pathophysiology of schizophrenia. The present study supports evidence for change in immune activation, probably of peripheral origin, in schizophrenic patients.
AB - Some evidence points towards a possible autoimmune role in the aetiology of schizophrenia. Experimental findings provide contradictory results regarding abnormalities in cytokine production in this disorder. In the present study we tested the production of cytokines in CSF and serum in 16 schizophrenic patients and 10 healthy controls (tumor necrosis factor a - TNFα; interleukins IL-1β, IL-2, IL-6, soluble IL-2 receptor). Cytokine levels were evaluated by radio-actively-labeled antibodies (IL-1β, IL-2, IL-6), by enzyme-linked immunoassay (TNF) and by a sandwich enzyme immunoassay (soluble IL-2 receptor). No significant differences were found in either CSF fluid or serum levels of TNF and IL-2 or IL-6. Interleukin-1β was significantly decreased in patients' CSF and serum as compared to controls. Soluble interleukin-2 receptor levels were decreased in CSF of patients, but highly increased in their serum in comparison with controls. Changes in various cytokine levels in CSF fluid and serum of schizophrenic patients probably reflect interrelated processes of growth, degeneration or neuroimmunological abnormalities, which may all play a role in the pathophysiology of schizophrenia. The present study supports evidence for change in immune activation, probably of peripheral origin, in schizophrenic patients.
UR - https://www.scopus.com/pages/publications/0028810366
U2 - 10.1515/JBCPP.1995.6.1.61
DO - 10.1515/JBCPP.1995.6.1.61
M3 - Article
AN - SCOPUS:0028810366
SN - 0792-6855
VL - 6
SP - 61
EP - 70
JO - Journal of Basic and Clinical Physiology and Pharmacology
JF - Journal of Basic and Clinical Physiology and Pharmacology
IS - 1
ER -