Changes in the coding sequence of the H-2Dk gene of metastatic cells that might account for immunogenic abnormality of its encoded antigen

Mordechai Aboud, Myriam Askenazi-Rydel, Iris Har-Vardi, Yacob Weinstein, Jacob Gopas, Shraga Segal

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

In previous studies we have demonstrated that metastic cells, derived from T-10 fibrosarcoma, express an immunogenically abnormal H-2Dk glycoprotein which is involved in manifesting their metastatic phenotype. In the present study we show that these cells contain a remarkably high level of H-2Dk specific mRNA. Moreover, by cloning cDNA of this gene and analyzing its nucleotide sequence, we found 4 single nucleotide changes. Two of them did not change the encoded amino acids, whereas the others resulted in two amino acid substitutions in the α-2 domain of the protein product that might account for its immunogenic abnormality.

Original languageEnglish
Pages (from-to)1395-1401
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume171
Issue number3
DOIs
StatePublished - 28 Sep 1990

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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