Chaperone networks are shaped by cellular differentiation and identity

Khairun Nisaa, Anat Ben-Zvi

Research output: Contribution to journalShort surveypeer-review

1 Scopus citations

Abstract

Chaperone expression is developmentally regulated, establishing tissue-specific networks. However, the molecular basis underlying this specificity is mainly unknown. Recent evidence suggests that chaperone network rewiring is mediated, in part, by differentiation transcription factors to fit the proteome folding demands, with implications for the tissue-specific manifestation of protein misfolding diseases.

Original languageEnglish
Pages (from-to)470-474
Number of pages5
JournalTrends in Cell Biology
Volume32
Issue number6
DOIs
StatePublished - 1 Jun 2022

Keywords

  • chaperone
  • differentiation
  • proteostasis
  • stress

ASJC Scopus subject areas

  • Cell Biology

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