Chaperone networks are shaped by cellular differentiation and identity

Khairun Nisaa; Anat Ben-Zvi

doi:10.1016/j.tcb.2021.11.001

Chaperone networks are shaped by cellular differentiation and identity

Khairun Nisaa, Anat Ben-Zvi

Department of Life Sciences

Research output: Contribution to journal › Short survey › peer-review

9 Scopus citations

Abstract

Chaperone expression is developmentally regulated, establishing tissue-specific networks. However, the molecular basis underlying this specificity is mainly unknown. Recent evidence suggests that chaperone network rewiring is mediated, in part, by differentiation transcription factors to fit the proteome folding demands, with implications for the tissue-specific manifestation of protein misfolding diseases.

Original language	English
Pages (from-to)	470-474
Number of pages	5
Journal	Trends in Cell Biology
Volume	32
Issue number	6
DOIs	https://doi.org/10.1016/j.tcb.2021.11.001
State	Published - 1 Jun 2022

Keywords

chaperone
differentiation
proteostasis
stress

ASJC Scopus subject areas

Cell Biology

Access to Document

10.1016/j.tcb.2021.11.001

Cite this

@article{dec05f459e0044f38b106d2a48cc0c03,

title = "Chaperone networks are shaped by cellular differentiation and identity",

abstract = "Chaperone expression is developmentally regulated, establishing tissue-specific networks. However, the molecular basis underlying this specificity is mainly unknown. Recent evidence suggests that chaperone network rewiring is mediated, in part, by differentiation transcription factors to fit the proteome folding demands, with implications for the tissue-specific manifestation of protein misfolding diseases.",

keywords = "chaperone, differentiation, proteostasis, stress",

author = "Khairun Nisaa and Anat Ben-Zvi",

note = "Publisher Copyright: {\textcopyright} 2021 Elsevier Ltd",

year = "2022",

month = jun,

day = "1",

doi = "10.1016/j.tcb.2021.11.001",

language = "English",

volume = "32",

pages = "470--474",

journal = "Trends in Cell Biology",

issn = "0962-8924",

publisher = "Elsevier Ltd.",

number = "6",

}

TY - JOUR

T1 - Chaperone networks are shaped by cellular differentiation and identity

AU - Nisaa, Khairun

AU - Ben-Zvi, Anat

PY - 2022/6/1

Y1 - 2022/6/1

N2 - Chaperone expression is developmentally regulated, establishing tissue-specific networks. However, the molecular basis underlying this specificity is mainly unknown. Recent evidence suggests that chaperone network rewiring is mediated, in part, by differentiation transcription factors to fit the proteome folding demands, with implications for the tissue-specific manifestation of protein misfolding diseases.

AB - Chaperone expression is developmentally regulated, establishing tissue-specific networks. However, the molecular basis underlying this specificity is mainly unknown. Recent evidence suggests that chaperone network rewiring is mediated, in part, by differentiation transcription factors to fit the proteome folding demands, with implications for the tissue-specific manifestation of protein misfolding diseases.

KW - chaperone

KW - differentiation

KW - proteostasis

KW - stress

UR - http://www.scopus.com/inward/record.url?scp=85120416542&partnerID=8YFLogxK

U2 - 10.1016/j.tcb.2021.11.001

DO - 10.1016/j.tcb.2021.11.001

M3 - Short survey

C2 - 34863585

AN - SCOPUS:85120416542

SN - 0962-8924

VL - 32

SP - 470

EP - 474

JO - Trends in Cell Biology

JF - Trends in Cell Biology

IS - 6

ER -

Chaperone networks are shaped by cellular differentiation and identity

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this