Chaperone networks are shaped by cellular differentiation and identity

Khairun Nisaa, Anat Ben-Zvi

Research output: Contribution to journalShort surveypeer-review

Abstract

Chaperone expression is developmentally regulated, establishing tissue-specific networks. However, the molecular basis underlying this specificity is mainly unknown. Recent evidence suggests that chaperone network rewiring is mediated, in part, by differentiation transcription factors to fit the proteome folding demands, with implications for the tissue-specific manifestation of protein misfolding diseases.

Original languageEnglish
JournalTrends in Cell Biology
DOIs
StateAccepted/In press - 1 Jan 2021

Keywords

  • chaperone
  • differentiation
  • proteostasis
  • stress

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