Chaperones and proteases: Cellular fold-controlling factors of proteins in neurodegenerative diseases and aging

Marie Pierre Hinault, Anat Ben-Zvi, Pierre Goloubinoff

Research output: Contribution to journalReview articlepeer-review

90 Scopus citations

Abstract

The formation of toxic protein aggregates is a common denominator to many neurodegenerative diseases and aging. Accumulation of toxic, possibly infectious protein aggregates induces a cascade of events, such as excessive inflammation, the production of reactive oxygen species, apoptosis and neuronal loss. A network of highly conserved molecular chaperones and of chaperone-related proteases controls the fold-quality of proteins in the cell. Most molecular chaperones can passively prevent protein aggregation by binding misfolding intermediates. Some molecular chaperones and chaperone-related proteases, such as the proteasome, can also hydrolyse ATP to forcefully convert stable harmful protein aggregates into harmless natively refoldable, or protease-degradable, polypeptides. Molecular chaperones and chaperone-related proteases thus control the delicate balance between natively folded functional proteins and aggregation-prone misfolded proteins, which may form during the lifetime and lead to cell death. Abundant data now point at the molecular chaperones and the proteases as major clearance mechanisms to remove toxic protein aggregates from cells, delaying the onset and the outcome of protein-misfolding diseases. Therapeutic approaches include treatments and drugs that can specifically induce and sustain a strong chaperone and protease activity in cells and tissues prone to toxic protein aggregations.

Original languageEnglish
Pages (from-to)249-265
Number of pages17
JournalJournal of Molecular Neuroscience
Volume30
Issue number3
DOIs
StatePublished - 1 Nov 2006
Externally publishedYes

Keywords

  • Aggresome
  • Fever
  • Heat shock proteins
  • Hsp27
  • Hsp70
  • Hsp90
  • Inflammation
  • NSAIDs
  • Proteasome

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

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