It is common to think about the adaptive immune system as having a memory. However, memory is always accompanied by the complementary process of oblivion. Is there immune oblivion? In this chapter, I address this question from a meaning-making perspective and suggest that memorization and oblivion are two necessary and complementary processes for meaning making and for attuning us for the context of the here and now. I inquire the implications on this idea for understanding immune memory and immune deficiency among the elderly. This case will help us to better understand the meaning of context.