TY - JOUR
T1 - Characteristics of pre-metastatic niche
T2 - the landscape of molecular and cellular pathways
AU - Wang, Hao
AU - Pan, Junjie
AU - Barsky, Livnat
AU - Jacob, Jule Caroline
AU - Zheng, Yan
AU - Gao, Chao
AU - Wang, Shun
AU - Zhu, Wenwei
AU - Sun, Haoting
AU - Lu, Lu
AU - Jia, Huliang
AU - Zhao, Yue
AU - Bruns, Christiane
AU - Vago, Razi
AU - Dong, Qiongzhu
AU - Qin, Lunxiu
N1 - Funding Information:
This work was supported by the National Key Research and Development Program of China (No. 2017YFC1308604), the National Natural Science Foundation of China (No. 81772563, 81802903 and 81930074), the Program of Shanghai Academic Research Leader (20XD1400900), the Joint Tackling Project of Emerging Frontier Technologies in Shanghai Hospitals in 2017 (SHDC12017122) and the NSFC Program of International Cooperation and Exchanges (No. 81120108016).
Funding Information:
The authors would like to thank Hangzhou Dixiang Co. Ltd., Hangzhou, China for help with retouching the figures.
Publisher Copyright:
© 2021, The Author(s).
PY - 2021/1/31
Y1 - 2021/1/31
N2 - Metastasis is a major contributor to cancer-associated deaths. It involves complex interactions between primary tumorigenic sites and future metastatic sites. Accumulation studies have revealed that tumour metastasis is not a disorderly spontaneous incident but the climax of a series of sequential and dynamic events including the development of a pre-metastatic niche (PMN) suitable for a subpopulation of tumour cells to colonize and develop into metastases. A deep understanding of the formation, characteristics and function of the PMN is required for developing new therapeutic strategies to treat tumour patients. It is rapidly becoming evident that therapies targeting PMN may be successful in averting tumour metastasis at an early stage. This review highlights the key components and main characteristics of the PMN and describes potential therapeutic strategies, providing a promising foundation for future studies.
AB - Metastasis is a major contributor to cancer-associated deaths. It involves complex interactions between primary tumorigenic sites and future metastatic sites. Accumulation studies have revealed that tumour metastasis is not a disorderly spontaneous incident but the climax of a series of sequential and dynamic events including the development of a pre-metastatic niche (PMN) suitable for a subpopulation of tumour cells to colonize and develop into metastases. A deep understanding of the formation, characteristics and function of the PMN is required for developing new therapeutic strategies to treat tumour patients. It is rapidly becoming evident that therapies targeting PMN may be successful in averting tumour metastasis at an early stage. This review highlights the key components and main characteristics of the PMN and describes potential therapeutic strategies, providing a promising foundation for future studies.
KW - Bone marrow-derived cells
KW - Extracellular vesicles
KW - Immunosuppression
KW - Metastasis
KW - Pre-metastatic niche
KW - Therapeutic strategies
KW - Vascular alteration
UR - http://www.scopus.com/inward/record.url?scp=85116592018&partnerID=8YFLogxK
U2 - 10.1186/s43556-020-00022-z
DO - 10.1186/s43556-020-00022-z
M3 - Review article
C2 - 35006432
SN - 2662-8651
VL - 2
JO - Molecular Biomedicine
JF - Molecular Biomedicine
IS - 1
M1 - 3
ER -
