Characteristics of pre-metastatic niche: the landscape of molecular and cellular pathways

Hao Wang, Junjie Pan, Livnat Barsky, Jule Caroline Jacob, Yan Zheng, Chao Gao, Shun Wang, Wenwei Zhu, Haoting Sun, Lu Lu, Huliang Jia, Yue Zhao, Christiane Bruns, Razi Vago, Qiongzhu Dong, Lunxiu Qin

Research output: Contribution to journalReview articlepeer-review

19 Scopus citations


Metastasis is a major contributor to cancer-associated deaths. It involves complex interactions between primary tumorigenic sites and future metastatic sites. Accumulation studies have revealed that tumour metastasis is not a disorderly spontaneous incident but the climax of a series of sequential and dynamic events including the development of a pre-metastatic niche (PMN) suitable for a subpopulation of tumour cells to colonize and develop into metastases. A deep understanding of the formation, characteristics and function of the PMN is required for developing new therapeutic strategies to treat tumour patients. It is rapidly becoming evident that therapies targeting PMN may be successful in averting tumour metastasis at an early stage. This review highlights the key components and main characteristics of the PMN and describes potential therapeutic strategies, providing a promising foundation for future studies.

Original languageEnglish
Article number3
Number of pages32
JournalMolecular Biomedicine
Issue number1
StatePublished - 31 Jan 2021


  • Bone marrow-derived cells
  • Extracellular vesicles
  • Immunosuppression
  • Metastasis
  • Pre-metastatic niche
  • Therapeutic strategies
  • Vascular alteration

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology


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