Characteristics of pre-metastatic niche: the landscape of molecular and cellular pathways

Hao Wang; Junjie Pan; Livnat Barsky; Jule Caroline Jacob; Yan Zheng; Chao Gao; Shun Wang; Wenwei Zhu; Haoting Sun; Lu Lu; Huliang Jia; Yue Zhao; Christiane Bruns; Razi Vago; Qiongzhu Dong; Lunxiu Qin

doi:10.1186/s43556-020-00022-z

Characteristics of pre-metastatic niche: the landscape of molecular and cellular pathways

Hao Wang, Junjie Pan, Livnat Barsky, Jule Caroline Jacob, Yan Zheng, Chao Gao, Shun Wang, Wenwei Zhu, Haoting Sun, Lu Lu, Huliang Jia, Yue Zhao, Christiane Bruns, Razi Vago, Qiongzhu Dong, Lunxiu Qin

Department of Biotechnology Engineering

Research output: Contribution to journal › Review article › peer-review

52 Scopus citations

Abstract

Metastasis is a major contributor to cancer-associated deaths. It involves complex interactions between primary tumorigenic sites and future metastatic sites. Accumulation studies have revealed that tumour metastasis is not a disorderly spontaneous incident but the climax of a series of sequential and dynamic events including the development of a pre-metastatic niche (PMN) suitable for a subpopulation of tumour cells to colonize and develop into metastases. A deep understanding of the formation, characteristics and function of the PMN is required for developing new therapeutic strategies to treat tumour patients. It is rapidly becoming evident that therapies targeting PMN may be successful in averting tumour metastasis at an early stage. This review highlights the key components and main characteristics of the PMN and describes potential therapeutic strategies, providing a promising foundation for future studies.

Original language	English
Article number	3
Number of pages	32
Journal	Molecular Biomedicine
Volume	2
Issue number	1
DOIs	https://doi.org/10.1186/s43556-020-00022-z
State	Published - 31 Jan 2021

Keywords

Bone marrow-derived cells
Extracellular vesicles
Immunosuppression
Metastasis
Pre-metastatic niche
Therapeutic strategies
Vascular alteration

ASJC Scopus subject areas

Molecular Medicine
Molecular Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1186/s43556-020-00022-z

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title = "Characteristics of pre-metastatic niche: the landscape of molecular and cellular pathways",

abstract = "Metastasis is a major contributor to cancer-associated deaths. It involves complex interactions between primary tumorigenic sites and future metastatic sites. Accumulation studies have revealed that tumour metastasis is not a disorderly spontaneous incident but the climax of a series of sequential and dynamic events including the development of a pre-metastatic niche (PMN) suitable for a subpopulation of tumour cells to colonize and develop into metastases. A deep understanding of the formation, characteristics and function of the PMN is required for developing new therapeutic strategies to treat tumour patients. It is rapidly becoming evident that therapies targeting PMN may be successful in averting tumour metastasis at an early stage. This review highlights the key components and main characteristics of the PMN and describes potential therapeutic strategies, providing a promising foundation for future studies.",

keywords = "Bone marrow-derived cells, Extracellular vesicles, Immunosuppression, Metastasis, Pre-metastatic niche, Therapeutic strategies, Vascular alteration",

author = "Hao Wang and Junjie Pan and Livnat Barsky and Jacob, {Jule Caroline} and Yan Zheng and Chao Gao and Shun Wang and Wenwei Zhu and Haoting Sun and Lu Lu and Huliang Jia and Yue Zhao and Christiane Bruns and Razi Vago and Qiongzhu Dong and Lunxiu Qin",

note = "Funding Information: This work was supported by the National Key Research and Development Program of China (No. 2017YFC1308604), the National Natural Science Foundation of China (No. 81772563, 81802903 and 81930074), the Program of Shanghai Academic Research Leader (20XD1400900), the Joint Tackling Project of Emerging Frontier Technologies in Shanghai Hospitals in 2017 (SHDC12017122) and the NSFC Program of International Cooperation and Exchanges (No. 81120108016). Funding Information: The authors would like to thank Hangzhou Dixiang Co. Ltd., Hangzhou, China for help with retouching the figures. Publisher Copyright: {\textcopyright} 2021, The Author(s).",

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doi = "10.1186/s43556-020-00022-z",

language = "English",

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T1 - Characteristics of pre-metastatic niche

T2 - the landscape of molecular and cellular pathways

AU - Wang, Hao

AU - Pan, Junjie

AU - Barsky, Livnat

AU - Jacob, Jule Caroline

AU - Zheng, Yan

AU - Gao, Chao

AU - Wang, Shun

AU - Zhu, Wenwei

AU - Sun, Haoting

AU - Lu, Lu

AU - Jia, Huliang

AU - Zhao, Yue

AU - Bruns, Christiane

AU - Vago, Razi

AU - Dong, Qiongzhu

AU - Qin, Lunxiu

N1 - Funding Information: This work was supported by the National Key Research and Development Program of China (No. 2017YFC1308604), the National Natural Science Foundation of China (No. 81772563, 81802903 and 81930074), the Program of Shanghai Academic Research Leader (20XD1400900), the Joint Tackling Project of Emerging Frontier Technologies in Shanghai Hospitals in 2017 (SHDC12017122) and the NSFC Program of International Cooperation and Exchanges (No. 81120108016). Funding Information: The authors would like to thank Hangzhou Dixiang Co. Ltd., Hangzhou, China for help with retouching the figures. Publisher Copyright: © 2021, The Author(s).

PY - 2021/1/31

Y1 - 2021/1/31

N2 - Metastasis is a major contributor to cancer-associated deaths. It involves complex interactions between primary tumorigenic sites and future metastatic sites. Accumulation studies have revealed that tumour metastasis is not a disorderly spontaneous incident but the climax of a series of sequential and dynamic events including the development of a pre-metastatic niche (PMN) suitable for a subpopulation of tumour cells to colonize and develop into metastases. A deep understanding of the formation, characteristics and function of the PMN is required for developing new therapeutic strategies to treat tumour patients. It is rapidly becoming evident that therapies targeting PMN may be successful in averting tumour metastasis at an early stage. This review highlights the key components and main characteristics of the PMN and describes potential therapeutic strategies, providing a promising foundation for future studies.

AB - Metastasis is a major contributor to cancer-associated deaths. It involves complex interactions between primary tumorigenic sites and future metastatic sites. Accumulation studies have revealed that tumour metastasis is not a disorderly spontaneous incident but the climax of a series of sequential and dynamic events including the development of a pre-metastatic niche (PMN) suitable for a subpopulation of tumour cells to colonize and develop into metastases. A deep understanding of the formation, characteristics and function of the PMN is required for developing new therapeutic strategies to treat tumour patients. It is rapidly becoming evident that therapies targeting PMN may be successful in averting tumour metastasis at an early stage. This review highlights the key components and main characteristics of the PMN and describes potential therapeutic strategies, providing a promising foundation for future studies.

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KW - Extracellular vesicles

KW - Immunosuppression

KW - Metastasis

KW - Pre-metastatic niche

KW - Therapeutic strategies

KW - Vascular alteration

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DO - 10.1186/s43556-020-00022-z

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JO - Molecular Biomedicine

JF - Molecular Biomedicine

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Characteristics of pre-metastatic niche: the landscape of molecular and cellular pathways

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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