Characterization of a polymeric PLGA-injectable implant delivery system for the controlled release of proteins

Rom E. Eliaz; Joseph Kost

doi:10.1002/(SICI)1097-4636(20000605)50:3<388::AID-JBM13>3.0.CO;2-F

Characterization of a polymeric PLGA-injectable implant delivery system for the controlled release of proteins

Rom E. Eliaz, Joseph Kost

Department of Chemical Engineering

Research output: Contribution to journal › Article › peer-review

156 Scopus citations

Abstract

Physico-chemical properties of injectable polymeric implant systems, based on the principle that a water-insoluble polymer dissolved in a biocompatible solvent will precipitate upon contact with water, were studied and utilized to predict the release of proteins from these systems. Polylactide-co-glycolide copolymer (PLGA) and glycofurol were chosen since they both have pharmaceutical precedence. Changes in polymer composition, its weight percent in solution, molecular weight, and protein loading level were assessed to provide formulations with the desired release rates and duration of release. (C) 2000 John Wiley and Sons, Inc.

Original language	English
Pages (from-to)	388-396
Number of pages	9
Journal	Journal of Biomedical Materials Research
Volume	50
Issue number	3
DOIs	https://doi.org/10.1002/(SICI)1097-4636(20000605)50:3<388::AID-JBM13>3.0.CO;2-F
State	Published - 12 Apr 2000

Keywords

Biodegradable polymers
In situ
Injectable implant
Peptide/protein delivery system
TNF soluble receptors

ASJC Scopus subject areas

Biomaterials
Biomedical Engineering

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10.1002/(SICI)1097-4636(20000605)50:3<388::AID-JBM13>3.0.CO;2-F

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AB - Physico-chemical properties of injectable polymeric implant systems, based on the principle that a water-insoluble polymer dissolved in a biocompatible solvent will precipitate upon contact with water, were studied and utilized to predict the release of proteins from these systems. Polylactide-co-glycolide copolymer (PLGA) and glycofurol were chosen since they both have pharmaceutical precedence. Changes in polymer composition, its weight percent in solution, molecular weight, and protein loading level were assessed to provide formulations with the desired release rates and duration of release. (C) 2000 John Wiley and Sons, Inc.

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KW - Injectable implant

KW - Peptide/protein delivery system

KW - TNF soluble receptors

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Characterization of a polymeric PLGA-injectable implant delivery system for the controlled release of proteins

Abstract

Keywords

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