Chemically-modified polysaccharides for enzymatically-controlled oral drug delivery

Joseph Kost, Shmuel Shefer

Research output: Contribution to journalArticlepeer-review

46 Scopus citations

Abstract

Starch polysaccharides were investigated as bioerodible matrices for enzymatically-controlled oral drug delivery. Corn starch was ionically cross-linked with calcium chloride. It was found that the cross-linked starch could be used for entrapment and controlled release of bioactive molecules. The release rate of large molecules was degradation-dependent due to amylase activity, which might target the release to the intestine, when the particles were taken orally. The release of small molecules such as salicyclic acid, was mainly by diffusion.

Original languageEnglish
Pages (from-to)695-698
Number of pages4
JournalBiomaterials
Volume11
Issue number9
DOIs
StatePublished - 1 Jan 1990

Keywords

  • Drug delivery
  • amylase
  • biodegradation
  • polysaccharide

ASJC Scopus subject areas

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials

Fingerprint

Dive into the research topics of 'Chemically-modified polysaccharides for enzymatically-controlled oral drug delivery'. Together they form a unique fingerprint.

Cite this