Chemoenzymatic synthesis of (R)-(+)-2-methylbutan-1-ol, a chiral synthon for the preparation of optically active pheromones

Shimona Geresh; Thomas J. Valiyaveettil; Yair Lavie; Arnon Shani

doi:10.1016/S0957-4166(97)00613-7

Chemoenzymatic synthesis of (R)-(+)-2-methylbutan-1-ol, a chiral synthon for the preparation of optically active pheromones

Shimona Geresh
, Thomas J. Valiyaveettil
, Yair Lavie
, Arnon Shani

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Optically active (R)-(+)-2-methylbutan-1-ol (which is not commercially available) was prepared by a chemoenzymatic synthesis, in which the key step involved a reduction catalyzed by baker's yeast. The synthon was used in the synthesis of (R)-10-methyldodecan-1-yl acetate, the chiral methyl-branched pheromone of Adoxophyes sp.

Original language	English
Pages (from-to)	89-96
Number of pages	8
Journal	Tetrahedron Asymmetry
Volume	9
Issue number	1
DOIs	https://doi.org/10.1016/S0957-4166(97)00613-7
State	Published - 16 Jan 1998

ASJC Scopus subject areas

Catalysis
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry

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abstract = "Optically active (R)-(+)-2-methylbutan-1-ol (which is not commercially available) was prepared by a chemoenzymatic synthesis, in which the key step involved a reduction catalyzed by baker's yeast. The synthon was used in the synthesis of (R)-10-methyldodecan-1-yl acetate, the chiral methyl-branched pheromone of Adoxophyes sp.",

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AU - Geresh, Shimona

AU - Valiyaveettil, Thomas J.

AU - Lavie, Yair

AU - Shani, Arnon

PY - 1998/1/16

Y1 - 1998/1/16

N2 - Optically active (R)-(+)-2-methylbutan-1-ol (which is not commercially available) was prepared by a chemoenzymatic synthesis, in which the key step involved a reduction catalyzed by baker's yeast. The synthon was used in the synthesis of (R)-10-methyldodecan-1-yl acetate, the chiral methyl-branched pheromone of Adoxophyes sp.

AB - Optically active (R)-(+)-2-methylbutan-1-ol (which is not commercially available) was prepared by a chemoenzymatic synthesis, in which the key step involved a reduction catalyzed by baker's yeast. The synthon was used in the synthesis of (R)-10-methyldodecan-1-yl acetate, the chiral methyl-branched pheromone of Adoxophyes sp.

UR - https://www.scopus.com/pages/publications/0344352483

U2 - 10.1016/S0957-4166(97)00613-7

DO - 10.1016/S0957-4166(97)00613-7

M3 - Article

AN - SCOPUS:0344352483

SN - 0957-4166

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JO - Tetrahedron Asymmetry

JF - Tetrahedron Asymmetry

IS - 1

ER -

Chemoenzymatic synthesis of (R)-(+)-2-methylbutan-1-ol, a chiral synthon for the preparation of optically active pheromones

Abstract

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