Chemoenzymatic synthesis of (R)-(+)-2-methylbutan-1-ol, a chiral synthon for the preparation of optically active pheromones

Shimona Geresh, Thomas J. Valiyaveettil, Yair Lavie, Arnon Shani

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Optically active (R)-(+)-2-methylbutan-1-ol (which is not commercially available) was prepared by a chemoenzymatic synthesis, in which the key step involved a reduction catalyzed by baker's yeast. The synthon was used in the synthesis of (R)-10-methyldodecan-1-yl acetate, the chiral methyl-branched pheromone of Adoxophyes sp.

Original languageEnglish
Pages (from-to)89-96
Number of pages8
JournalTetrahedron Asymmetry
Volume9
Issue number1
DOIs
StatePublished - 16 Jan 1998

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