Chlamydia elleni IgA és IgG antitestek IgA nephropathiás, mesangiocapillaris és membranosus glomerulonephritises betegekben.

Translated title of the contribution: IgA and IgG antibodies to Chlamydia in IgA nephropathy as well as in mesangiocapillary and membranous glomerulonephritis

J. Nagy, I. Sarov, J. Sámik, C. Trinn, L. Kun, T. Burger, B. Sarov

    Research output: Contribution to journalReview articlepeer-review

    Abstract

    It might be supposed that, among the antigens causing chronic immune complex glomerulonephritis (IC GN), there are foreign materials, e.g. bacterial antigens penetrating the mucosal barrier. To put this hypothesis to the test, the presence and titres of IgA and IgG antibodies against Chlamydia (C., one of the most frequent bacteria causing mucosal inflammation) have been studied in the sera of 70 patients with IgA nephropathy (IgA NP), of 25 with mesangiocapillary GN (MCGN) and of 27 with membranous GN (MGN) using a single serovar (L2) inclusion immunoperoxidase assay. Significantly more IgA (titres greater than or equal to 8) and IgG (titres greater than or equal to 32) antibodies were found in the sera of IgA NP and MCGN patients than in healthy controls. These results are compatible with the hypothesis that there are some similarities between the clinical and morphological picture of IgA NP and MCGN. Furthermore, it may be assumed that in renal patients with an active C. infection (high IgG titres with IgA seropositivity) C. antigens may play a role in the production of nephropathogenic IC developing in antibody excess.

    Translated title of the contributionIgA and IgG antibodies to Chlamydia in IgA nephropathy as well as in mesangiocapillary and membranous glomerulonephritis
    Original languageHungarian
    Pages (from-to)1527-1530
    Number of pages4
    JournalOrvosi Hetilap
    Volume130
    Issue number29
    StatePublished - 16 Jul 1989

    ASJC Scopus subject areas

    • Medicine (all)

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