Chlamydia pneumoniae and future risk in patients with coronary heart disease

Moti Haim, David Tanne, Alexander Battler, Valentina Boyko, Tamar Reshef, Uri Goldbourt, Daniel Brunner, Yoseph A. Mekori, Solomon Behar

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Aim: To evaluate the association between previous exposure to Chlamydia pneumoniae and future coronary risk in patients with coronary heart disease. Methods: A prospective, nested, case-control design was used. The patient sample was derived from a trial study of bezafibrate for the treatment of coronary heart disease. Anti-Chlamydia pneumoniae antibodies (IgG and IgA) in the baseline sera of 136 patients who had coronary events during follow-up (mean 6.2 years) were compared with those in 136 age- and gender-matched patients from the same trial without subsequent coronary events. Results: Mean titers of IgG and IgA antibodies were similar in cases and controls. The relative odds of future coronary events in patients who were seropositive at baseline were 1.0 (95% CI, 0.54-1.84) for IgG and 0.74 (95% CI, 0.41-1.31) for IgA. The relative odds did not change after adjustment for multiple confounding variables. The risk of future coronary events did not increase with increasing anti-Chlamydia pneumoniae antibody titers. Conclusions: Prior exposure to Chlamydia pneumoniae in patients with chronic coronary heart disease is not associated with increased risk of recurrent coronary events.

Original languageEnglish
Pages (from-to)25-30
Number of pages6
JournalInternational Journal of Cardiology
Volume93
Issue number1
DOIs
StatePublished - 1 Jan 2004
Externally publishedYes

Keywords

  • Chlamydia pneumoniae
  • Coronary heart disease
  • Infection

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