Chlamydia trachomatis and HIV infection

Ami Schattner, Negba Hanuka, Batya Sarov, Zvi Bentwich

    Research output: Contribution to journalArticlepeer-review

    4 Scopus citations


    To study the interactions between Chlamydia trachomatis (CT) and human immunodeficiency virus (HIV) infections, we examined CT serologies in sequential serum samples of male homosexuals (MHS), followed over a mean period of 4 years. Of the MHS studied, 77 were HIV(-), 18 were HIV(+) and 10 patients seroconverted during the study period. Seventy matched heterosexual controls were tested concomitantly. CT-specific antibodies of both IgG and IgA isotypes were determined by an immunoperoxidase assay, indicating past and active infection respectively. Anti-CT IgG was frequently observed in both HIV(-) and HIV(+) MHS (40-50% vs. 23% of controls) and IgA antibodies were also common in both MHS groups (15-20% vs. 1.5% of controls). After HIV infection, no increase in CT antibodies occurred. We found serological data suggestive of active CT infection preceding seroconversion in 3 of 10 seroconverters vs. 5% of matched MHS controls who remained HIV(-) (P < 0.025), indicating a possible effect of CT infection on the acquisition of HIV should be further studied.

    Original languageEnglish
    Pages (from-to)27-30
    Number of pages4
    JournalImmunology Letters
    Issue number1
    StatePublished - 1 Jan 1994


    • AIDS
    • Chlamydia
    • Human immunodeficiency virus

    ASJC Scopus subject areas

    • Immunology and Allergy
    • Immunology


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