Chromatic Dendrimer/Polydiacetylene Nanoparticles

Reut Israeli, Sofiya Kolusheva, Pablo Mateos-Gil, Electra Gizeli, Raz Jelinek

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Polydiacetylenes (PDAs) constitute a unique class of chromatic conjugated polymers, and their optical properties have been employed in diverse biological and chemical diagnostic applications. We constructed composite nanoparticles (NPs) comprising PDA and a dendritic amphiphilic polymer. The dendrimer/PDA NPs exhibit structural and chromatic stability and constitute an excellent platform for sensing and analysis of biomolecular membrane interactions, both in model vesicle systems and in a live-cell environment. Interestingly, the dendritic polymer shielded the PDA matrix and modulated its interactions with external stimuli such as heat and amphiphilic biomolecules. Furthermore, the dendrimer-layer-mediated association of the composite NPs with lipid bilayers in giant vesicles and live mammalian cells, thereby facilitating microscopic analysis of lipid bilayer interactions in actual membrane environments. The dendrimer/PDA NPs may serve as a broad-based vehicle for analysis of membrane interactions in diverse model and natural environments.

Original languageEnglish
Pages (from-to)2931-2937
Number of pages7
JournalACS Applied Polymer Materials
Volume3
Issue number6
DOIs
StatePublished - 11 Jun 2021

Keywords

  • acoustic sensing
  • cell labeling
  • dendrimer
  • hyperbranched polymers
  • polydiacetylene
  • polymer nanoparticles

ASJC Scopus subject areas

  • Polymers and Plastics
  • Process Chemistry and Technology
  • Organic Chemistry

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