Evaluation of the extent of lipoprotein oxidation and the effects of therapeutic and dietary agents upon lipid peroxidation processes are critical in understanding and combating atherosclerotic diseases. Bioanalytical chromatic assays based upon polydiacetylene (PDA) have recently emerged as a useful platform for analysis of lipoprotein oxidation. This article describes the principles of PDA-based sensing, and its application to the study of lipids peroxidation, both in purified lipoprotein samples, as well as in blood plasma specimens.
ASJC Scopus subject areas
- Control and Systems Engineering
- Food Science
- Biochemistry, Genetics and Molecular Biology (all)