Chromosomal organization is shaped by the transcription regulatory network

Ruth Hershberg, Esti Yeger-Lotem, Hanah Margalit

Research output: Contribution to journalArticlepeer-review

60 Scopus citations


Transcription regulation, a key step in the control of gene expression, has been the focus of several large-scale studies; however, little attention has been given to its relationship with the chromosomal arrangement of transcription units. We studied this relationship systematically in Escherichia coli and Saccharomyces cerevisiae using network analysis methods. Our analysis reveals links between transcription regulation and chromosomal organization, suggesting that in both organisms transcription regulation has shaped the organization of transcription units on the chromosome. Differences found between the organisms reflect the inherent differences in transcription regulation between prokaryotes and eukaryotes.

Original languageEnglish
Pages (from-to)138-142
Number of pages5
JournalTrends in Genetics
Issue number3
StatePublished - 1 Jan 2005
Externally publishedYes

ASJC Scopus subject areas

  • Genetics


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