Chronic dietary inositol enhances locomotor activity and brain inositol levels in rats

Ora Kofman; Galila Agam; Joseph Shapiro; Abby Spencer

doi:10.1007/s002130050710

Chronic dietary inositol enhances locomotor activity and brain inositol levels in rats

Ora Kofman, Galila Agam, Joseph Shapiro, Abby Spencer

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

myo-Inositol has been found to be clinically effective in depression, obsessive compulsive disorder (OCD) and panic disorder when given chronically per os. The present study examined the effects of chronic dietary inositol in rats on locomotor behaviour. Regional brain levels of inositol were analyzed by gas chromatography. Chronic dietary inositol significantly enhanced locomotion and rearing in rats and elevated inositol levels by 36% in the cortex and 27% in hippocampus. No differences in inositol levels were found in the striatum or cerebellum. The stimulatory effects of inositol may be related to its effects as an atypical antidepressant in depressed patients.

Original language	English
Pages (from-to)	239-242
Number of pages	4
Journal	Psychopharmacology
Volume	139
Issue number	3
DOIs	https://doi.org/10.1007/s002130050710
State	Published - 7 Oct 1998

Keywords

Inositol
Locomotor behaviour
Rearing

ASJC Scopus subject areas

Pharmacology

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10.1007/s002130050710

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title = "Chronic dietary inositol enhances locomotor activity and brain inositol levels in rats",

abstract = "myo-Inositol has been found to be clinically effective in depression, obsessive compulsive disorder (OCD) and panic disorder when given chronically per os. The present study examined the effects of chronic dietary inositol in rats on locomotor behaviour. Regional brain levels of inositol were analyzed by gas chromatography. Chronic dietary inositol significantly enhanced locomotion and rearing in rats and elevated inositol levels by 36% in the cortex and 27% in hippocampus. No differences in inositol levels were found in the striatum or cerebellum. The stimulatory effects of inositol may be related to its effects as an atypical antidepressant in depressed patients.",

keywords = "Inositol, Locomotor behaviour, Rearing",

author = "Ora Kofman and Galila Agam and Joseph Shapiro and Abby Spencer",

note = "Funding Information: Acknowledgements This research was supported by grant 3627 from the Chief Scientist, Ministry of Health, Israel, to O.K.",

year = "1998",

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T1 - Chronic dietary inositol enhances locomotor activity and brain inositol levels in rats

AU - Kofman, Ora

AU - Agam, Galila

AU - Shapiro, Joseph

AU - Spencer, Abby

N1 - Funding Information: Acknowledgements This research was supported by grant 3627 from the Chief Scientist, Ministry of Health, Israel, to O.K.

PY - 1998/10/7

Y1 - 1998/10/7

N2 - myo-Inositol has been found to be clinically effective in depression, obsessive compulsive disorder (OCD) and panic disorder when given chronically per os. The present study examined the effects of chronic dietary inositol in rats on locomotor behaviour. Regional brain levels of inositol were analyzed by gas chromatography. Chronic dietary inositol significantly enhanced locomotion and rearing in rats and elevated inositol levels by 36% in the cortex and 27% in hippocampus. No differences in inositol levels were found in the striatum or cerebellum. The stimulatory effects of inositol may be related to its effects as an atypical antidepressant in depressed patients.

AB - myo-Inositol has been found to be clinically effective in depression, obsessive compulsive disorder (OCD) and panic disorder when given chronically per os. The present study examined the effects of chronic dietary inositol in rats on locomotor behaviour. Regional brain levels of inositol were analyzed by gas chromatography. Chronic dietary inositol significantly enhanced locomotion and rearing in rats and elevated inositol levels by 36% in the cortex and 27% in hippocampus. No differences in inositol levels were found in the striatum or cerebellum. The stimulatory effects of inositol may be related to its effects as an atypical antidepressant in depressed patients.

KW - Inositol

KW - Locomotor behaviour

KW - Rearing

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DO - 10.1007/s002130050710

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JO - Psychopharmacology

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ER -

Chronic dietary inositol enhances locomotor activity and brain inositol levels in rats

Abstract

Keywords

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