Chronic electroconvulsive shock and chronic haloperidol administration are not additive in effects on dopamine receptors

Electroconvulsive shock applied daily for 7 days caused a dopaminergic supersensitivity to apomorphine, without an increase in ³H spiperone binding. Chronic administration of haloperidol for 4 weeks caused a dopaminergic supersensitivity to apomorphine with an increase in ³H spiperone binding. The present experiment shows that, despite these apparent differences in mechanisms, the two treatments are not additive. Four weeks of haloperidol treatment plus 7 daily electroconvulsive shocks caused no more in crease in apomorphine-induced stereotypy than four weeks of haloperidol treatment alone.