Chronic hypertension is an independent risk factor for preeclampsia and preterm delivery in women with rheumatologic diseases: A population-based study

Amit Mayer, Offer Erez, Lena Novack, Asher Bashiri, Arnon Wiznitzer, Moshe Mazor

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Objective: The objective was to determine the prevalence of maternal and perinatal complications among patients with rheumatologic diseases (RD) and to investigate the maternal risk factors for preeclampsia and preterm delivery among RD patients. Study design: A retrospective population-based cohort study was conducted. The study group comprised women with RD; the control group comprised patients without RD. The obstetric and neonatal outcomes of the groups were compared, and the data were obtained from a computerized database. Results: During the study period, there were 179 deliveries by 125 women with RD. The prevalence of severe preeclampsia, chronic hypertension, pregestational diabetes, oligohydramnios, preterm deliveries and cesarean sections was significantly higher in the RD group than in the control group. Mean birth weight was significantly lower in the study group compared with the general population. Maternal RD was found to be an independent risk factor for preterm delivery and severe preeclampsia (OR 3.59; 95% CI: 2.52-5.11; OR 3.05; 95% CI: 1.44-6.45, respectively). The presence of chronic hypertension in patients with RD was found to be an independent risk factor for severe preeclampsia and preterm delivery (OR 12.2; 95% CI: 2.1-69.8; OR 3.8; 95% CI: 1.1-12.7, respectively). Conclusion: Chronic hypertension is an independent risk factor for preterm delivery and severe preeclampsia among RD patients.

Original languageEnglish
Pages (from-to)157-163
Number of pages7
JournalEuropean Journal of Obstetrics, Gynecology and Reproductive Biology
Volume133
Issue number2
DOIs
StatePublished - 1 Jan 2007
Externally publishedYes

Keywords

  • Chronic hypertension
  • Preeclampsia
  • Preterm delivery
  • Rheumatologic disease

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