Chronic lithium treatment and dopamine-mediated behavior

R. P. Ebstein, S. Eliashar, R. H. Belmaker, Y. Ben-Uriah, S. Yehuda

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

The effect of 3-4 weeks of chronic lithium (Li) treatment in food on amphetamine-induced stereotypy, hyperactivity, and hypothermia was examined. The long-term Li treatment failed to inhibit these behaviors and even resulted in small but statistically significant potentiation of stereotypy and hypothermia. The absence of an inhibitory effect of Li on these dopaminergic processes is consistent with Li's lack of antischizophrenic properties. Previous studies reporting conflicting results, including lithium inhibition of amphetamine-induced hyperactivity, used acute or very short-term lithium administration and/or did not verify serum lithium levels to be at therapeutically equivalent levels.

Original languageEnglish
Pages (from-to)459-467
Number of pages9
JournalBiological Psychiatry
Volume15
Issue number3
StatePublished - 1 Dec 1980
Externally publishedYes

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