Chronic parasite infections cause immune changes that could affect successful vaccination

Gadi Borkow, Zvi Bentwich

Research output: Contribution to journalShort surveypeer-review

39 Scopus citations

Abstract

Several important issues must be considered when performing any vaccination in areas with high prevalence of geohelminths. Immunization of populations infected with geohelminths could be sub-optimal if the immune background is not taken into consideration. Immune modulation and deworming might be essential for effective protective vaccination. In addition, further animal models and clinical studies addressing these issues are required. Underscoring the importance of these issues, a recent report has highlighted several vaccination studies in which nematode-infected mice or pigs failed to mount efficient protective immune responses.

Original languageEnglish
Pages (from-to)243-245
Number of pages3
JournalTrends in Parasitology
Volume24
Issue number6
DOIs
StatePublished - 1 Jun 2008

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