Clinical and epidemiologic investigation of two Legionella-Rickettsia co-infections

Michael Huerta, Hana Castel, Itamar Grotto, Ofer Shpilberg, Michael Alkan, Ilana Harman-Boehm

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Background: We treated two patients diagnosed with legionellosis and simultaneous Rickettsia conorii co-infection. Objectives: To report the clinical and laboratory characteristics of this unusual combination, and to describe the execution and results of our environmental and epidemiologic investigations. Methods: Serial serologic testing was conducted 1,4 and 7 weeks after initial presentation. Water samples from the patients' residence were cultured for Legionella. Follow-up cultures were taken from identical points at 2 weeks and at 3 months after the initial survey. Results: Both patients initially expressed a non-specific rise in anti-Legionella immunoglobulin M liters to multiple serotypes. By week 4 a definite pattern of specifically elevated IgG titers became apparent, with patient 1 demonstrating a rise in specific anti-L pneumophila 12 IgG liter, and patient 2 an identical response to L. jordanis. At 4 weeks both patients were positive for both IgM and IgG anti-R. conorii antibodies at a titer ≥ 1:100. Heavy growth of Legionella was found in water sampled from the shower heads in the rooms of both patients. Indirect immunofluorescence of water cultures was positive for L. pneumophila 12 and for L jordanis. Conclusions: Although most cases of community-acquired Legionella pneumonia in our region appear simultaneously with at least one other causative agent, co-infection with R. conorii is unusual and has not been reported to date. This report illustrates the importance of cooperation between clinicians and public health practitioners.

Original languageEnglish
Pages (from-to)560-563
Number of pages4
JournalIsrael Medical Association Journal
Volume5
Issue number8
StatePublished - 1 Aug 2003

Keywords

  • Co-infection
  • Epidemiologic investigation
  • Legionella
  • Rickettsia

ASJC Scopus subject areas

  • Medicine (all)

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