Clinical and Molecular Characterization of a Rare Case of BNT162b2 mRNA COVID-19 Vaccine-Associated Myositis

Eli Magen; Sumit Mukherjee; Mahua Bhattacharya; Rajesh Detroja; Eugene Merzon; Idan Blum; Alejandro Livoff; Mark Shlapobersky; Gideon Baum; Ran Talisman; Evgenia Cherniavsky; Amir Dori; Milana Frenkel-Morgenstern

doi:10.3390/vaccines10071135

Clinical and Molecular Characterization of a Rare Case of BNT162b2 mRNA COVID-19 Vaccine-Associated Myositis

Eli Magen, Sumit Mukherjee, Mahua Bhattacharya, Rajesh Detroja, Eugene Merzon, Idan Blum, Alejandro Livoff, Mark Shlapobersky, Gideon Baum, Ran Talisman, Evgenia Cherniavsky, Amir Dori, Milana Frenkel-Morgenstern

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Initial clinical trials and surveillance data have shown that the most commonly administered BNT162b2 COVID-19 mRNA vaccine is effective and safe. However, several cases of mRNA vaccine-induced mild to moderate adverse events were recently reported. Here, we report a rare case of myositis after injection of the first dose of BNT162b2 COVID-19 mRNA vaccine into the left deltoid muscle of a 34-year-old, previously healthy woman who presented progressive proximal muscle weakness, progressive dysphagia, and dyspnea with respiratory failure. One month after vaccination, BNT162b2 vaccine mRNA expression was detected in a tissue biopsy of the right deltoid and quadriceps muscles. We propose this case as a rare example of COVID-19 mRNA vaccine-induced myositis. This study comprehensively characterizes the clinical and molecular features of BNT162b2 mRNA vaccine-associated myositis in which the patient was severely affected.

Original language	English
Article number	1135
Journal	Vaccines
Volume	10
Issue number	7
DOIs	https://doi.org/10.3390/vaccines10071135
State	Published - 1 Jul 2022

Keywords

BNT162b2
COVID-19
mRNA vaccine
myositis

ASJC Scopus subject areas

Immunology
Pharmacology
Drug Discovery
Infectious Diseases
Pharmacology (medical)

Access to Document

10.3390/vaccines10071135

Cite this

Magen, E., Mukherjee, S., Bhattacharya, M., Detroja, R., Merzon, E., Blum, I., Livoff, A., Shlapobersky, M., Baum, G., Talisman, R., Cherniavsky, E., Dori, A., & Frenkel-Morgenstern, M. (2022). Clinical and Molecular Characterization of a Rare Case of BNT162b2 mRNA COVID-19 Vaccine-Associated Myositis. Vaccines, 10(7), Article 1135. https://doi.org/10.3390/vaccines10071135

@article{d1a3ff6daa2149459838f7f475a5810e,

title = "Clinical and Molecular Characterization of a Rare Case of BNT162b2 mRNA COVID-19 Vaccine-Associated Myositis",

abstract = "Initial clinical trials and surveillance data have shown that the most commonly administered BNT162b2 COVID-19 mRNA vaccine is effective and safe. However, several cases of mRNA vaccine-induced mild to moderate adverse events were recently reported. Here, we report a rare case of myositis after injection of the first dose of BNT162b2 COVID-19 mRNA vaccine into the left deltoid muscle of a 34-year-old, previously healthy woman who presented progressive proximal muscle weakness, progressive dysphagia, and dyspnea with respiratory failure. One month after vaccination, BNT162b2 vaccine mRNA expression was detected in a tissue biopsy of the right deltoid and quadriceps muscles. We propose this case as a rare example of COVID-19 mRNA vaccine-induced myositis. This study comprehensively characterizes the clinical and molecular features of BNT162b2 mRNA vaccine-associated myositis in which the patient was severely affected.",

keywords = "BNT162b2, COVID-19, mRNA vaccine, myositis",

author = "Eli Magen and Sumit Mukherjee and Mahua Bhattacharya and Rajesh Detroja and Eugene Merzon and Idan Blum and Alejandro Livoff and Mark Shlapobersky and Gideon Baum and Ran Talisman and Evgenia Cherniavsky and Amir Dori and Milana Frenkel-Morgenstern",

note = "Publisher Copyright: {\textcopyright} 2022 by the authors.",

year = "2022",

month = jul,

day = "1",

doi = "10.3390/vaccines10071135",

language = "English",

volume = "10",

journal = "Vaccines",

issn = "2076-393X",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "7",

}

TY - JOUR

T1 - Clinical and Molecular Characterization of a Rare Case of BNT162b2 mRNA COVID-19 Vaccine-Associated Myositis

AU - Magen, Eli

AU - Mukherjee, Sumit

AU - Bhattacharya, Mahua

AU - Detroja, Rajesh

AU - Merzon, Eugene

AU - Blum, Idan

AU - Livoff, Alejandro

AU - Shlapobersky, Mark

AU - Baum, Gideon

AU - Talisman, Ran

AU - Cherniavsky, Evgenia

AU - Dori, Amir

AU - Frenkel-Morgenstern, Milana

PY - 2022/7/1

Y1 - 2022/7/1

N2 - Initial clinical trials and surveillance data have shown that the most commonly administered BNT162b2 COVID-19 mRNA vaccine is effective and safe. However, several cases of mRNA vaccine-induced mild to moderate adverse events were recently reported. Here, we report a rare case of myositis after injection of the first dose of BNT162b2 COVID-19 mRNA vaccine into the left deltoid muscle of a 34-year-old, previously healthy woman who presented progressive proximal muscle weakness, progressive dysphagia, and dyspnea with respiratory failure. One month after vaccination, BNT162b2 vaccine mRNA expression was detected in a tissue biopsy of the right deltoid and quadriceps muscles. We propose this case as a rare example of COVID-19 mRNA vaccine-induced myositis. This study comprehensively characterizes the clinical and molecular features of BNT162b2 mRNA vaccine-associated myositis in which the patient was severely affected.

AB - Initial clinical trials and surveillance data have shown that the most commonly administered BNT162b2 COVID-19 mRNA vaccine is effective and safe. However, several cases of mRNA vaccine-induced mild to moderate adverse events were recently reported. Here, we report a rare case of myositis after injection of the first dose of BNT162b2 COVID-19 mRNA vaccine into the left deltoid muscle of a 34-year-old, previously healthy woman who presented progressive proximal muscle weakness, progressive dysphagia, and dyspnea with respiratory failure. One month after vaccination, BNT162b2 vaccine mRNA expression was detected in a tissue biopsy of the right deltoid and quadriceps muscles. We propose this case as a rare example of COVID-19 mRNA vaccine-induced myositis. This study comprehensively characterizes the clinical and molecular features of BNT162b2 mRNA vaccine-associated myositis in which the patient was severely affected.

KW - BNT162b2

KW - COVID-19

KW - mRNA vaccine

KW - myositis

UR - http://www.scopus.com/inward/record.url?scp=85136086794&partnerID=8YFLogxK

U2 - 10.3390/vaccines10071135

DO - 10.3390/vaccines10071135

M3 - Article

AN - SCOPUS:85136086794

SN - 2076-393X

VL - 10

JO - Vaccines

JF - Vaccines

IS - 7

M1 - 1135

ER -

Clinical and Molecular Characterization of a Rare Case of BNT162b2 mRNA COVID-19 Vaccine-Associated Myositis

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this