Clinical and molecular epidemiology of Acinetobacter baumannii bloodstream infections in an endemic setting

Dror Marchaim, Dana Levit, Roy Zigron, Michal Gordon, Tsillia Lazarovitch, Joao A. Carrico, Vered Chalifa-Caspi, Jacob Moran-Gilad

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Aim: The transmission dynamics of Acinetobacter baumannii in endemic settings, and the relation between microbial properties and patients' clinical outcomes, are yet obscure and hampered by insufficient metadata. Methods & Results: Of 20 consecutive patients with A. baumannii bloodstream infection that were thoroughly analyzed at a single center, at least one transmission opportunity was evident for 85% of patients. This implies that patient-to-patient transmission is the major mode of A. baumannii acquisitions in health facilities. Moreover, all patients who died immediately (<24 h of admission) were infected with a single clone (ST457; relative risk = 1.6; p = 0.05). Conclusion: This preliminary analysis should prompt further investigation by mapping genomic virulence determinants among A. baumannii ST457 lineage compared with other strains.

Original languageEnglish
Pages (from-to)271-283
Number of pages13
JournalFuture Microbiology
Volume12
Issue number4
DOIs
StatePublished - 1 Mar 2017

Keywords

  • Gram-negative
  • MDR
  • MLST
  • carbapenem
  • nonfermenter
  • nosocomial infections
  • typing

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)

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