Clinical characteristics and outcomes of elderly patients treated with an implantable cardioverter-defibrillator or cardiac resynchronization therapy in a real-world setting: Data from the Israeli ICD Registry

Mahmoud Suleiman, Ilan Goldenberg, Moti Haim, Jorge E. Schliamser, Monther Boulos, Michael Ilan, Moshe Swissa, Natalie Gavrielov-Yusim, Therese Fuchs, Guy Amit, Michael Glikson

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

Background Elderly patients are underrepresented in clinical trials of device therapy. Objective To provide real-world data regarding outcomes associated with device-based therapy in a large cohort of elderly patients enrolled in the Israeli ICD Registry. Methods Between July 2010 and June 2012, a total of 2807 consecutive patients undergoing implanted cardioverter- defibrillator/cardiac resynchronization therapy-defibrillator (ICD/CRT-D) implantation were prospectively enrolled in the Israeli ICD Registry. For the present analysis, patients were categorized into 3 age groups: ≤60 years (n = 1378 [49%]), 61-75 years (n = 863 [31%]), and >75 years (n = 566 [20%]). Results Elderly patients (>75 years of age) had more comorbid conditions and were more likely to undergo CRT-D implantation (all P <.01). However, the rate of device-related complications associated with surgical reinterventions at 1 year was <3% regardless of age (P =.70 for the comparison among the 3 age groups). Multivariate analysis showed that the risk of heart failure or death and of appropriate ICD therapy for ventricular arrhythmias was significantly increased with increasing age among patients who received an ICD. In contrast, the age-related increase in the risk of all end points was attenuated among patients who received CRT-D devices (all P values for age-by-device-type interactions are <.05). Conclusions In a real-world scenario, elderly patients (>75 years of age) comprise approximately 20% of the ICD/CRT-D recipients and experience a device reintervention rate similar to that of their younger counterparts. Our data suggest that the association between advanced age and adverse clinical outcomes is attenuated in elderly patients implanted with CRT-D devices.

Original languageEnglish
Pages (from-to)435-441
Number of pages7
JournalHeart Rhythm
Volume11
Issue number3
DOIs
StatePublished - 1 Mar 2014
Externally publishedYes

Keywords

  • Defibrillators
  • Elderly
  • Outcomes
  • Resynchronization

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