Clinical significance and impact on mortality of extended-spectrum beta lactamase-producing Enterobacteriaceae isolates in nosocomial bacteremia

G. Menashe, A. Borer, P. Yagupsky, N. Peled, J. Gilad, D. Fraser, K. Riesenberg, F. Schlaeffer

Research output: Contribution to journalArticlepeer-review

70 Scopus citations

Abstract

During an 8-month period, 55 episodes of nosocomial bacteremia caused by Enterobacteriaceae species were identified in a tertiary medical center, of which 26 (47%) were caused by extended-spectrum beta lactamase (ESBL)-producing organisms. ESBL production was associated with resistance to aminoglycosides, fluoroquinolones, tetracycline and co-trimoxazole compared with non-ESBL-producing organisms (p<0.01). By multivariate analysis, infection with ESBL-producing organisms was associated with previous antibiotic therapy and central venous catheter insertion and mortality was associated with heart failure, malignancy and a prolonged hospital stay. Nineteen (73%) patients infected with ESBL-producing organisms received adequate empirical antibiotic therapy and all 26 received adequate definitive therapy. The in-hospital mortality rate did not differ between patients infected with ESBL producers and those infected by non-ESBL-producing Enterobacteriaceae species [13/26 (50%) and 11/29 (38%), respectively (p>0.5).

Original languageEnglish
Pages (from-to)188-193
Number of pages6
JournalScandinavian Journal of Infectious Diseases
Volume33
Issue number3
DOIs
StatePublished - 11 Apr 2001

ASJC Scopus subject areas

  • Immunology and Microbiology (all)
  • Microbiology (medical)
  • Infectious Diseases

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