Clinical studies in pediatric respiratory-tract infections: What is desirable, feasible, or simply misleading

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

In recent years, attempts have been made to make the regulatory requirements for clinical studies more uniform, and much has been discussed on the issue of good clinical practice. There is no doubt that clinical trials involving new drugs have to be conducted according to the highest standards. However, ideal design is not always feasible or ethical. The ideal design for efficacy studies demands randomization, double-blind comparisons, adequate group size, specification of the type of patients and isolated organisms. The present paper points out some difficulties regarding these points when studying cephalosporins in pediatric respiratory-tract infections, and proposes some solutions.

Original languageEnglish
Pages (from-to)18-24
Number of pages7
JournalChemotherapy
Volume38
Issue numberSUPPL. 2
DOIs
StatePublished - 1 Jan 1992
Externally publishedYes

Keywords

  • Antibiotics
  • Cephalosporins
  • Clinical studies
  • Methodology
  • Respiratory-tract infections

ASJC Scopus subject areas

  • Oncology
  • Pharmacology
  • Drug Discovery
  • Pharmacology (medical)
  • Infectious Diseases

Fingerprint

Dive into the research topics of 'Clinical studies in pediatric respiratory-tract infections: What is desirable, feasible, or simply misleading'. Together they form a unique fingerprint.

Cite this