Clinically nonfunctioning pituitary tumors

Michal Ehrenwald, Merav Fraenkel, Dror Limon, Michal Raz, Rachel Grossman, Yona Greenman

    Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


    NFPAs are clinically silent tumors that develop from different pituitary lineages. Their classification landscape has changed with the recognition that even in the absence of evidence of hormone production based on immunohistochemistry, they can be assigned to specific lineages based on staining for transcription factors. Early evidence suggests that the clinical behavior of transcription factor positive/hormone negative tumors is similar to that of transcription factor positive/hormone positive tumors. Whether these findings, if confirmed, will have significant implications on the clinical management of NFPA remains to be established. There is consensus regarding surgery as the first-line treatment of these often large tumors, which present with clinical signs and symptoms of mass effect. However, the optimal postsurgical management is still a matter of debate. The selection of tumors that need adjuvant treatment, as well as the timing and type of medical and/or radiation therapy, remains to be established.

    Original languageEnglish
    Title of host publicationPituitary Tumors
    Subtitle of host publicationA Comprehensive and Interdisciplinary Approach
    Number of pages9
    ISBN (Electronic)9780128199497
    StatePublished - 1 Jan 2021


    • Dopamine agonist
    • Mass effect
    • Nonfunctioning
    • Pituitary
    • Silent tumor

    ASJC Scopus subject areas

    • General Medicine
    • General Neuroscience


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