Clotiapine: An old neuroleptic with possible clozapine-like properties

Pavel Lokshin, Moshe Kotler, Dani Kutzuk, Robert H. Belmaker

    Research output: Contribution to journalArticlepeer-review

    9 Scopus citations


    1. This chart survey aims to draw attention to a neuroleptic drug which is poorly known but may have atypical properties. 2. Forty patients, thirty four of them suffering from chronic schizophrenia resistant to other neuroleptics, were found to be in clotiapine treatment. A clinical evaluation was made by the treating doctors and medical personnel. 3. More than sixty percent of the patients suffering from chronic schizophrenia showed significant improvement and more than thirty five percent showed partial improvement, compared with past function on other neuroleptics. 4. Clotiapine may have clozapine-like effects that require controlled study for confirmation.

    Original languageEnglish
    Pages (from-to)1289-1293
    Number of pages5
    JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
    Issue number8
    StatePublished - 1 Nov 1998


    • Atypical neuroleptics
    • Clotiapine
    • Clozapine

    ASJC Scopus subject areas

    • Pharmacology
    • Biological Psychiatry


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