Cl- as a bona fide signaling ion

Benjamin P. Lüscher, Laura Vachel, Ehud Ohana, Shmuel Muallem

Research output: Contribution to journalReview articlepeer-review

36 Scopus citations


Cl- is the major extracellular (Cl- out) and intracellular (Cl- in) anion whose concentration is actively regulated by multiple transporters. These transporters generate Cl- gradients across the plasma membrane and between the cytoplasm and intracellular organelles. [Cl-]in changes rapidly in response to cell stimulation and influences many physiological functions, as well as cellular and systemic homeostasis. However, less appreciated is the signaling function of Cl-. Cl- interacts with multiple proteins to directly modify their activity. This review highlights the signaling function of Cl- and argues that Cl- is a bona fide signaling ion, a function deserving extensive exploration.

Original languageEnglish
Pages (from-to)C125-C136
JournalAmerican Journal of Physiology - Cell Physiology
Issue number1
StatePublished - 1 Jan 2020


  • Chloride
  • Signaling

ASJC Scopus subject areas

  • Physiology
  • Cell Biology


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