Abstract
Coagulation factors were determined in twelve hypothermic infants. Three of the infants developed bleeding complications and two others died despite vigorous therapy. Four of the infants had a decreased platelet count, and three others had a prolonged prothrombin and partial thromboplastin time. Sera from hypothermic infants induced less serotonin release from normal platelets than normal sera. Seven of the hypothermic infants but none of the control infants had a level of antithrombin III activity lower than 55%. No significant differences in protein C antigenicity, total protein S and alpha 2 antiplasmin activity were found. Bleeding complications in hypothermic infants might result from a defect in platelet number and/or function.
| Original language | English |
|---|---|
| Pages (from-to) | 327-333 |
| Number of pages | 7 |
| Journal | Pediatric Reviews and Communications |
| Volume | 3 |
| Issue number | 4 |
| State | Published - 1 Jan 1989 |
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health