Coarse-grained molecular simulations of membrane adhesion domains

Nadiv Dharan, Oded Farago

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


We use a coarse-grained molecular model of supported lipid bilayers to study the formation of adhesion domains. We find that this process is a first order phase transition, triggered by a combination of pairwise short range attractive interactions between the adhesion bonds and many-body Casimir-like interactions, mediated by the membrane thermal undulations. The simulation results display an excellent agreement with the recently proposed Weil-Farago two-dimensional lattice model, in which the occupied and empty sites represent, respectively, the adhesion bonds and unbound segments of the membrane. A second phase transition, into a hexatic phase, is observed when the attraction between the adhesion bonds is further strengthened.

Original languageEnglish
Article number024903
JournalJournal of Chemical Physics
Issue number2
StatePublished - 14 Jul 2014

ASJC Scopus subject areas

  • General Physics and Astronomy
  • Physical and Theoretical Chemistry


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