Cocaine pharmacology and current pharmacotherapies for its abuse

M. Rocío A. Carrera; Michael M. Meijler; Kim D. Janda

doi:10.1016/j.bmc.2004.06.018

Cocaine pharmacology and current pharmacotherapies for its abuse

M. Rocío A. Carrera, Michael M. Meijler, Kim D. Janda

Research output: Contribution to journal › Review article › peer-review

47 Scopus citations

Abstract

Cocaine abuse continues to be prevalent and effective therapies for cocaine craving and addiction remain elusive. In the last decade immunopharmacotherapy has been proposed as a promising means to alleviate this illness. By using the organism's natural immune response, an anti-cocaine vaccine promotes the production of cocaine-specific antibodies that sequester the drug before their passage into the brain, where it exerts its reinforcing and thus addictive effects. A series of studies demonstrating the cocaine-blocking properties of various immunogenic conjugates will be reviewed in the context of the neuropsychopharmacological profile of the drug.

Original language	English
Pages (from-to)	5019-5030
Number of pages	12
Journal	Bioorganic and Medicinal Chemistry
Volume	12
Issue number	19
DOIs	https://doi.org/10.1016/j.bmc.2004.06.018
State	Published - 1 Oct 2004
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.bmc.2004.06.018

Cite this

@article{44c97377497b451196a19630a8b296ea,

title = "Cocaine pharmacology and current pharmacotherapies for its abuse",

abstract = "Cocaine abuse continues to be prevalent and effective therapies for cocaine craving and addiction remain elusive. In the last decade immunopharmacotherapy has been proposed as a promising means to alleviate this illness. By using the organism's natural immune response, an anti-cocaine vaccine promotes the production of cocaine-specific antibodies that sequester the drug before their passage into the brain, where it exerts its reinforcing and thus addictive effects. A series of studies demonstrating the cocaine-blocking properties of various immunogenic conjugates will be reviewed in the context of the neuropsychopharmacological profile of the drug.",

author = "Carrera, {M. Roc{\'i}o A.} and Meijler, {Michael M.} and Janda, {Kim D.}",

note = "Funding Information: The authors would like to thank Prof. George Koob and his laboratory members for many years of pleasant and outstanding collaboration, Dr. Tobin Dickerson for his assistance in editing this manuscript and Mr. Edward Fishwick for his valuable contribution for the completion of this work. The work by the Janda laboratory reported in this review was supported in part by The Skaggs Institute for Chemical Biology and the National Institute on Drug Abuse Grants DA015700, DA08590, and DA016478. ",

year = "2004",

month = oct,

day = "1",

doi = "10.1016/j.bmc.2004.06.018",

language = "English",

volume = "12",

pages = "5019--5030",

journal = "Bioorganic and Medicinal Chemistry",

issn = "0968-0896",

publisher = "Elsevier Ltd.",

number = "19",

}

TY - JOUR

T1 - Cocaine pharmacology and current pharmacotherapies for its abuse

AU - Carrera, M. Rocío A.

AU - Meijler, Michael M.

AU - Janda, Kim D.

N1 - Funding Information: The authors would like to thank Prof. George Koob and his laboratory members for many years of pleasant and outstanding collaboration, Dr. Tobin Dickerson for his assistance in editing this manuscript and Mr. Edward Fishwick for his valuable contribution for the completion of this work. The work by the Janda laboratory reported in this review was supported in part by The Skaggs Institute for Chemical Biology and the National Institute on Drug Abuse Grants DA015700, DA08590, and DA016478.

PY - 2004/10/1

Y1 - 2004/10/1

N2 - Cocaine abuse continues to be prevalent and effective therapies for cocaine craving and addiction remain elusive. In the last decade immunopharmacotherapy has been proposed as a promising means to alleviate this illness. By using the organism's natural immune response, an anti-cocaine vaccine promotes the production of cocaine-specific antibodies that sequester the drug before their passage into the brain, where it exerts its reinforcing and thus addictive effects. A series of studies demonstrating the cocaine-blocking properties of various immunogenic conjugates will be reviewed in the context of the neuropsychopharmacological profile of the drug.

AB - Cocaine abuse continues to be prevalent and effective therapies for cocaine craving and addiction remain elusive. In the last decade immunopharmacotherapy has been proposed as a promising means to alleviate this illness. By using the organism's natural immune response, an anti-cocaine vaccine promotes the production of cocaine-specific antibodies that sequester the drug before their passage into the brain, where it exerts its reinforcing and thus addictive effects. A series of studies demonstrating the cocaine-blocking properties of various immunogenic conjugates will be reviewed in the context of the neuropsychopharmacological profile of the drug.

UR - http://www.scopus.com/inward/record.url?scp=4444368820&partnerID=8YFLogxK

U2 - 10.1016/j.bmc.2004.06.018

DO - 10.1016/j.bmc.2004.06.018

M3 - Review article

C2 - 15351386

AN - SCOPUS:4444368820

SN - 0968-0896

VL - 12

SP - 5019

EP - 5030

JO - Bioorganic and Medicinal Chemistry

JF - Bioorganic and Medicinal Chemistry

IS - 19

ER -

Cocaine pharmacology and current pharmacotherapies for its abuse

Abstract

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this