Cochlear neural degeneration disrupts hearing in background noise by increasing auditory cortex internal noise

Jennifer Resnik, Daniel B. Polley

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

Resnik and Polley show that selective difficulty hearing in noise can be induced in mice through degeneration of primary afferent neurons in the auditory nerve. Primary afferent lesions dysregulate activity in the auditory cortex, producing surges of noisy, synchronized activity that specifically preceded failures to detect target sounds in noise.

Original languageEnglish
Pages (from-to)984-996.e4
JournalNeuron
Volume109
Issue number6
DOIs
StatePublished - 17 Mar 2021
Externally publishedYes

Keywords

  • auditory cortex
  • hearing in noise
  • hidden hearing loss
  • homeostatic plasticity
  • nerve damage
  • neuropathy
  • parvalbumin
  • spiral ganglion
  • synaptopathy
  • two-photon calcium imaging

ASJC Scopus subject areas

  • Neuroscience (all)

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