Cochlear neural degeneration disrupts hearing in background noise by increasing auditory cortex internal noise

Jennifer Resnik; Daniel B. Polley

doi:10.1016/j.neuron.2021.01.015

Cochlear neural degeneration disrupts hearing in background noise by increasing auditory cortex internal noise

Jennifer Resnik
, Daniel B. Polley

Research output: Contribution to journal › Article › peer-review

101 Scopus citations

Abstract

Resnik and Polley show that selective difficulty hearing in noise can be induced in mice through degeneration of primary afferent neurons in the auditory nerve. Primary afferent lesions dysregulate activity in the auditory cortex, producing surges of noisy, synchronized activity that specifically preceded failures to detect target sounds in noise.

Original language	English
Pages (from-to)	984-996.e4
Journal	Neuron
Volume	109
Issue number	6
DOIs	https://doi.org/10.1016/j.neuron.2021.01.015
State	Published - 17 Mar 2021
Externally published	Yes

Keywords

auditory cortex
hearing in noise
hidden hearing loss
homeostatic plasticity
nerve damage
neuropathy
parvalbumin
spiral ganglion
synaptopathy
two-photon calcium imaging

ASJC Scopus subject areas

General Neuroscience

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10.1016/j.neuron.2021.01.015

Cite this

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title = "Cochlear neural degeneration disrupts hearing in background noise by increasing auditory cortex internal noise",

abstract = "Resnik and Polley show that selective difficulty hearing in noise can be induced in mice through degeneration of primary afferent neurons in the auditory nerve. Primary afferent lesions dysregulate activity in the auditory cortex, producing surges of noisy, synchronized activity that specifically preceded failures to detect target sounds in noise.",

keywords = "auditory cortex, hearing in noise, hidden hearing loss, homeostatic plasticity, nerve damage, neuropathy, parvalbumin, spiral ganglion, synaptopathy, two-photon calcium imaging",

author = "Jennifer Resnik and Polley, \{Daniel B.\}",

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year = "2021",

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AU - Polley, Daniel B.

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N2 - Resnik and Polley show that selective difficulty hearing in noise can be induced in mice through degeneration of primary afferent neurons in the auditory nerve. Primary afferent lesions dysregulate activity in the auditory cortex, producing surges of noisy, synchronized activity that specifically preceded failures to detect target sounds in noise.

AB - Resnik and Polley show that selective difficulty hearing in noise can be induced in mice through degeneration of primary afferent neurons in the auditory nerve. Primary afferent lesions dysregulate activity in the auditory cortex, producing surges of noisy, synchronized activity that specifically preceded failures to detect target sounds in noise.

KW - auditory cortex

KW - hearing in noise

KW - hidden hearing loss

KW - homeostatic plasticity

KW - nerve damage

KW - neuropathy

KW - parvalbumin

KW - spiral ganglion

KW - synaptopathy

KW - two-photon calcium imaging

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U2 - 10.1016/j.neuron.2021.01.015

DO - 10.1016/j.neuron.2021.01.015

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AN - SCOPUS:85101721516

SN - 0896-6273

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JO - Neuron

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ER -

Cochlear neural degeneration disrupts hearing in background noise by increasing auditory cortex internal noise

Abstract

Keywords

ASJC Scopus subject areas

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