Coexistence of ischemic heart disease and rheumatoid arthritis patients-A case control study

Esther Houri Levi, Abdulla Watad, Aaron Whitby, Shmuel Tiosano, Doron Comaneshter, Arnon D. Cohen, Howard Amital

    Research output: Contribution to journalReview articlepeer-review

    53 Scopus citations


    Background: Over the last few decades, several studies have demonstrated the connection between Rheumatoid Arthritis (RA) and Ischemic Heart Disease (IHD). The additional risk for RA patients to also suffer from IHD varies based on the definition of the diseases in question, the populations evaluated, and the variables included in the studies. Objectives: To quantify the association between RA and IHD according to certain demographics as well as traditional cardiovascular risk factors in order to determine their roles in the development of coronary artery disease among patients with RA. Methods: Using data from the largest HMO in Israel, the Clalit Health Services, we selected for patients with RA. These patients were compared with age and sex matched controls with regards to the prevalence of IHD in a case-control study.Chi-square and t-tests were used for univariate analysis and a logistic regression model was used for multivariate analysis. Results: The study included 11,782 patients with RA and 57,973 age and sex matched controls. The prevalence of IHD in patients with RA was increased compared with the prevalence in controls (16.6% and 12.8% respectively, P < 0.001). In a multivariate analysis, RA was associated with higher proportions of IHD (OR 1.346, 95% confidence interval 1.255-1.431).

    Original languageEnglish
    Pages (from-to)393-396
    Number of pages4
    JournalAutoimmunity Reviews
    Issue number4
    StatePublished - 1 Apr 2016


    • Acute coronary syndrome
    • Autoimmune disease
    • Comorbidity
    • Ischemic heart disease
    • RA
    • Rheumatic diseases

    ASJC Scopus subject areas

    • Immunology and Allergy
    • Immunology


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