TY - JOUR
T1 - Cognitive function and the risk for diabetes among young men
AU - Twig, Gilad
AU - Gluzman, Israel
AU - Tirosh, Amir
AU - Gerstein, Hertzel C.
AU - Yaniv, Gal
AU - Afek, Arnon
AU - Derazne, Estela
AU - Tzur, Dorit
AU - Karasik, Avraham
AU - Gordon, Barak
AU - Fruchter, Eyal
AU - Lubin, Gadi
AU - Rudich, Assaf
AU - Cukierman-Yaffe, Tali
N1 - Publisher Copyright:
© 2014 by the American Diabetes Association.
PY - 2014/11/1
Y1 - 2014/11/1
N2 - OBJECTIVE: Diabetes is a risk factor for an accelerated rate of cognitive decline and dementia. However, the relationship between cognitive function and the subsequent development of diabetes is unclear. RESEARCH DESIGN AND METHODS: We conducted a historical-prospective cohort study merging data collected at premilitary recruitment assessment with information collected at the Staff Periodic Examination Center of the Israeli Army Medical Corps. Included were men aged 25 years or older without a history of diabetes at the beginning of follow-up with available data regarding their general intelligence score (GIS), a comprehensive measure of cognitive function, at age 17 years. RESULTS: Among 35,500 men followed for a median of 5.5 years, 770 new cases of diabetes were diagnosed. After adjustment for age, participants in the lowest GIS category had a 2.6-fold greater risk for developing diabetes compared with those in the highest GIS category. In multivariable analysis adjusted for age, BMI, fasting plasma glucose, sociogenetic variables, and lifestyle risk factors, those in the lowest GIS category had a twofold greater risk for incident diabetes when compared with the highest GIS category (hazard ratio 2.1 [95% CI 1.5 -3.1]; P < 0.001). Additionally, participants in the lowest GIS category developed diabetes at a mean age of 39.5 ± 4.7 years and those in the highest GIS group at amean age of 41.5 ± 5.1 years (P for comparison 0.042). CONCLUSIONS: This study demonstrates that in addition to a potential causal link between diabetes and enhanced cognitive decline, lower cognitive function at late adolescence is independently associated with an elevated risk for future diabetes.
AB - OBJECTIVE: Diabetes is a risk factor for an accelerated rate of cognitive decline and dementia. However, the relationship between cognitive function and the subsequent development of diabetes is unclear. RESEARCH DESIGN AND METHODS: We conducted a historical-prospective cohort study merging data collected at premilitary recruitment assessment with information collected at the Staff Periodic Examination Center of the Israeli Army Medical Corps. Included were men aged 25 years or older without a history of diabetes at the beginning of follow-up with available data regarding their general intelligence score (GIS), a comprehensive measure of cognitive function, at age 17 years. RESULTS: Among 35,500 men followed for a median of 5.5 years, 770 new cases of diabetes were diagnosed. After adjustment for age, participants in the lowest GIS category had a 2.6-fold greater risk for developing diabetes compared with those in the highest GIS category. In multivariable analysis adjusted for age, BMI, fasting plasma glucose, sociogenetic variables, and lifestyle risk factors, those in the lowest GIS category had a twofold greater risk for incident diabetes when compared with the highest GIS category (hazard ratio 2.1 [95% CI 1.5 -3.1]; P < 0.001). Additionally, participants in the lowest GIS category developed diabetes at a mean age of 39.5 ± 4.7 years and those in the highest GIS group at amean age of 41.5 ± 5.1 years (P for comparison 0.042). CONCLUSIONS: This study demonstrates that in addition to a potential causal link between diabetes and enhanced cognitive decline, lower cognitive function at late adolescence is independently associated with an elevated risk for future diabetes.
UR - http://www.scopus.com/inward/record.url?scp=84910121285&partnerID=8YFLogxK
U2 - 10.2337/dc14-0715
DO - 10.2337/dc14-0715
M3 - Article
C2 - 25092683
AN - SCOPUS:84910121285
SN - 0149-5992
VL - 37
SP - 2982
EP - 2988
JO - Diabetes Care
JF - Diabetes Care
IS - 11
ER -