Coiled fiber scaffolds embedded with gold nanoparticles improve the performance of engineered cardiac tissues

Sharon Fleischer; Michal Shevach; Ron Feiner; Tal Dvir

doi:10.1039/c4nr00300d

Coiled fiber scaffolds embedded with gold nanoparticles improve the performance of engineered cardiac tissues

Sharon Fleischer
, Michal Shevach
, Ron Feiner
, Tal Dvir

Research output: Contribution to journal › Article › peer-review

144 Scopus citations

Abstract

Coiled perimysial fibers within the heart muscle provide it with the ability to contract and relax efficiently. Here, we report on a new nanocomposite scaffold for cardiac tissue engineering, integrating coiled electrospun fibers with gold nanoparticles. Cultivation of cardiac cells within the hybrid scaffolds promoted cell organization into elongated and aligned tissues generating a strong contraction force, high contraction rate and low excitation threshold.

Original language	English
Pages (from-to)	9410-9414
Number of pages	5
Journal	Nanoscale
Volume	6
Issue number	16
DOIs	https://doi.org/10.1039/c4nr00300d
State	Published - 21 Aug 2014
Externally published	Yes

ASJC Scopus subject areas

General Materials Science

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10.1039/c4nr00300d

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title = "Coiled fiber scaffolds embedded with gold nanoparticles improve the performance of engineered cardiac tissues",

abstract = "Coiled perimysial fibers within the heart muscle provide it with the ability to contract and relax efficiently. Here, we report on a new nanocomposite scaffold for cardiac tissue engineering, integrating coiled electrospun fibers with gold nanoparticles. Cultivation of cardiac cells within the hybrid scaffolds promoted cell organization into elongated and aligned tissues generating a strong contraction force, high contraction rate and low excitation threshold.",

author = "Sharon Fleischer and Michal Shevach and Ron Feiner and Tal Dvir",

year = "2014",

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doi = "10.1039/c4nr00300d",

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AU - Fleischer, Sharon

AU - Shevach, Michal

AU - Feiner, Ron

AU - Dvir, Tal

PY - 2014/8/21

Y1 - 2014/8/21

N2 - Coiled perimysial fibers within the heart muscle provide it with the ability to contract and relax efficiently. Here, we report on a new nanocomposite scaffold for cardiac tissue engineering, integrating coiled electrospun fibers with gold nanoparticles. Cultivation of cardiac cells within the hybrid scaffolds promoted cell organization into elongated and aligned tissues generating a strong contraction force, high contraction rate and low excitation threshold.

AB - Coiled perimysial fibers within the heart muscle provide it with the ability to contract and relax efficiently. Here, we report on a new nanocomposite scaffold for cardiac tissue engineering, integrating coiled electrospun fibers with gold nanoparticles. Cultivation of cardiac cells within the hybrid scaffolds promoted cell organization into elongated and aligned tissues generating a strong contraction force, high contraction rate and low excitation threshold.

UR - https://www.scopus.com/pages/publications/84905157777

U2 - 10.1039/c4nr00300d

DO - 10.1039/c4nr00300d

M3 - Article

C2 - 24744098

AN - SCOPUS:84905157777

SN - 2040-3364

VL - 6

SP - 9410

EP - 9414

JO - Nanoscale

JF - Nanoscale

IS - 16

ER -

Coiled fiber scaffolds embedded with gold nanoparticles improve the performance of engineered cardiac tissues

Abstract

ASJC Scopus subject areas

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