Colorectal cancer biomarkers and the potential role of cancer stem cells

Russell C. Langan; John E. Mullinax; Manish T. Raiji; Trevor Upham; Thomas Summers; Alexander Stojadinovic; Itzhak Avital

doi:10.7150/jca.5832

Colorectal cancer biomarkers and the potential role of cancer stem cells

Russell C. Langan, John E. Mullinax, Manish T. Raiji, Trevor Upham, Thomas Summers, Alexander Stojadinovic, Itzhak Avital

Research output: Contribution to journal › Review article › peer-review

71 Scopus citations

Abstract

Over 50% of patients with colorectal cancer (CRC) will progress and/or develop metastases. Biomarkers capable of predicting progression, risk stratification and therapeutic benefit are needed. Cancer stem cells are thought to be responsible for tumor initiation, dissemination and treatment failure. Therefore, we hypothesized that CRC stem cell markers (CRCSC) can identify a group of patients whom are at increased risk for recurrence or progression of disease. If proven correct, these CRCSC biomarkers may herald a paradigm shift in the treatment of this deadly disease. This manuscript reviews current CRC evidence based screening modalities, patient stratification, and summarizes the current state of biomarkers and discusses the novel concept of putative CRCSC's as prognostic biomarkers.

Original language	English
Pages (from-to)	241-250
Number of pages	10
Journal	Journal of Cancer
Volume	4
Issue number	3
DOIs	https://doi.org/10.7150/jca.5832
State	Published - 24 Sep 2013
Externally published	Yes

Keywords

Biomarkers
Cancer stem cells
Colorectal cancer

ASJC Scopus subject areas

Oncology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.7150/jca.5832

Cite this

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title = "Colorectal cancer biomarkers and the potential role of cancer stem cells",

abstract = "Over 50% of patients with colorectal cancer (CRC) will progress and/or develop metastases. Biomarkers capable of predicting progression, risk stratification and therapeutic benefit are needed. Cancer stem cells are thought to be responsible for tumor initiation, dissemination and treatment failure. Therefore, we hypothesized that CRC stem cell markers (CRCSC) can identify a group of patients whom are at increased risk for recurrence or progression of disease. If proven correct, these CRCSC biomarkers may herald a paradigm shift in the treatment of this deadly disease. This manuscript reviews current CRC evidence based screening modalities, patient stratification, and summarizes the current state of biomarkers and discusses the novel concept of putative CRCSC's as prognostic biomarkers.",

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AU - Langan, Russell C.

AU - Mullinax, John E.

AU - Raiji, Manish T.

AU - Upham, Trevor

AU - Summers, Thomas

AU - Stojadinovic, Alexander

AU - Avital, Itzhak

PY - 2013/9/24

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N2 - Over 50% of patients with colorectal cancer (CRC) will progress and/or develop metastases. Biomarkers capable of predicting progression, risk stratification and therapeutic benefit are needed. Cancer stem cells are thought to be responsible for tumor initiation, dissemination and treatment failure. Therefore, we hypothesized that CRC stem cell markers (CRCSC) can identify a group of patients whom are at increased risk for recurrence or progression of disease. If proven correct, these CRCSC biomarkers may herald a paradigm shift in the treatment of this deadly disease. This manuscript reviews current CRC evidence based screening modalities, patient stratification, and summarizes the current state of biomarkers and discusses the novel concept of putative CRCSC's as prognostic biomarkers.

AB - Over 50% of patients with colorectal cancer (CRC) will progress and/or develop metastases. Biomarkers capable of predicting progression, risk stratification and therapeutic benefit are needed. Cancer stem cells are thought to be responsible for tumor initiation, dissemination and treatment failure. Therefore, we hypothesized that CRC stem cell markers (CRCSC) can identify a group of patients whom are at increased risk for recurrence or progression of disease. If proven correct, these CRCSC biomarkers may herald a paradigm shift in the treatment of this deadly disease. This manuscript reviews current CRC evidence based screening modalities, patient stratification, and summarizes the current state of biomarkers and discusses the novel concept of putative CRCSC's as prognostic biomarkers.

KW - Biomarkers

KW - Cancer stem cells

KW - Colorectal cancer

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JO - Journal of Cancer

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Colorectal cancer biomarkers and the potential role of cancer stem cells

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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