Combination drug delivery approaches for cancer therapy

Gowtham Kenguva, Ravi Bandaru, Smruti Rekha Rout, Rambabu Dandela, Khaled Greish, Prashant Kesharwani

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

3 Scopus citations

Abstract

Cancer is considered as one of the deadliest diseases in the world. Every year millions of people are affected by various kinds of cancers. Although various treatment procedures are developed to treat cancer, complete eradication of cancer is still a challenge for scientists, biologists, and cancer specialists. The most recent advancement in chemotherapy is combination drug therapy, in which more than one chemotherapeutic agent is administered simultaneously with a goal to achieve improved efficacy, better pharmacokinetic properties, synergistic effect, and reduction in toxicity. Most of the chemotherapeutic agents are cytotoxic and lack target specificity in drug delivery approaches, so there is a necessity to protect normal cells from these agents in chemotherapy. In order to achieve this, nanocarriers are used for better results in combinational drug delivery. Nanocarriers work like transporters, which deliver the drug to the target organ instead of other organs in the body and contribute to altering the physicochemical properties of drugs which leads to increased therapeutic efficacy. In this chapter, we will discuss the importance of combinational drug delivery approaches in cancer treatment. Furthermore, the role of various nanocarriers in combinational drug delivery to treat breast cancer, lung cancer, cervical cancer, colorectal cancer, and prostate cancer is discussed.

Original languageEnglish
Title of host publicationCombination Drug Delivery Approach as an Effective Therapy for Various Diseases
PublisherElsevier
Pages213-237
Number of pages25
ISBN (Electronic)9780323858731
ISBN (Print)9780323858762
DOIs
StatePublished - 1 Jan 2022
Externally publishedYes

Keywords

  • cancer therapy
  • Combination of drug
  • combination of therapy
  • drug delivery
  • nanocarriers
  • therapeutic activity

ASJC Scopus subject areas

  • General Economics, Econometrics and Finance
  • General Business, Management and Accounting

Fingerprint

Dive into the research topics of 'Combination drug delivery approaches for cancer therapy'. Together they form a unique fingerprint.

Cite this