Abstract
Cancer is considered as one of the deadliest diseases in the world. Every year millions of people are affected by various kinds of cancers. Although various treatment procedures are developed to treat cancer, complete eradication of cancer is still a challenge for scientists, biologists, and cancer specialists. The most recent advancement in chemotherapy is combination drug therapy, in which more than one chemotherapeutic agent is administered simultaneously with a goal to achieve improved efficacy, better pharmacokinetic properties, synergistic effect, and reduction in toxicity. Most of the chemotherapeutic agents are cytotoxic and lack target specificity in drug delivery approaches, so there is a necessity to protect normal cells from these agents in chemotherapy. In order to achieve this, nanocarriers are used for better results in combinational drug delivery. Nanocarriers work like transporters, which deliver the drug to the target organ instead of other organs in the body and contribute to altering the physicochemical properties of drugs which leads to increased therapeutic efficacy. In this chapter, we will discuss the importance of combinational drug delivery approaches in cancer treatment. Furthermore, the role of various nanocarriers in combinational drug delivery to treat breast cancer, lung cancer, cervical cancer, colorectal cancer, and prostate cancer is discussed.
Original language | English |
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Title of host publication | Combination Drug Delivery Approach as an Effective Therapy for Various Diseases |
Publisher | Elsevier |
Pages | 213-237 |
Number of pages | 25 |
ISBN (Electronic) | 9780323858731 |
ISBN (Print) | 9780323858762 |
DOIs | |
State | Published - 1 Jan 2022 |
Externally published | Yes |
Keywords
- cancer therapy
- Combination of drug
- combination of therapy
- drug delivery
- nanocarriers
- therapeutic activity
ASJC Scopus subject areas
- General Economics, Econometrics and Finance
- General Business, Management and Accounting