Combined multimodal approach to the treatment of metastatic anal carcinoma: Report of a case and review of the literature

Margarita Tokar, Dmitri Bobilev, Svetlana Zalmanov, David B. Geffen, Shlomo Walfisch

Research output: Contribution to journalReview articlepeer-review

26 Scopus citations

Abstract

Background: We report on a patient with squamous cell anal carcinoma and liver metastases, who underwent multimodal treatment for cure, consisting of repeated partial hepatectomy in combination with chemoradiotherapy. Patients and Methods: A 54-year-old woman presented with squamous cell anal carcinoma and liver metastases. She was treated with a combination of chemoradiotherapy for the primary tumor and then underwent surgery for liver metastases. 2 and 5 years after presentation, the patient underwent repeated partial hepatectomies for recurrent liver disease. At present, 5 months after completing therapy and 71 months after the initial diagnosis, she is in good health with no evidence of disease. Results: Repeated partial hepatectomy led to prolonged survival in a patient with squamous cell anal carcinoma metastatic to the liver. Conclusions: This is the first report of aggressive partial hepatectomy for recurrent liver metastases resulting from anal cancer. Based on our experience, we suggest that in selected patients repeated hepatectomy should be part of an aggressive multimodal treatment program with curative intent.

Original languageEnglish
Pages (from-to)30-32
Number of pages3
JournalOnkologie
Volume29
Issue number1-2
DOIs
StatePublished - 1 Jan 2006
Externally publishedYes

Keywords

  • Anal carcinoma, metastatic
  • Chemotherapy
  • Hepatectomy, partial
  • Long-term survival
  • Radiotherapy

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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