TY - JOUR
T1 - Common gene signature of cancer and longevity
AU - Budovsky, Arie
AU - Tacutu, Robi
AU - Yanai, Hagai
AU - Abramovich, Amir
AU - Wolfson, Marina
AU - Fraifeld, Vadim
N1 - Funding Information:
This study was supported in part by grant from the Israel Cancer Association (to V.F. and M.W.). Preliminary results on domain–domain interactions were obtained in collaboration with Zohar Itzhaki from Hanah Margalit's Lab of Computational Biology (Bioinformatics), Department of Molecular Genetics and Biotechnology, Faculty of Medicine, The Hebrew University of Jerusalem. We appreciate the assistance of I. Eli Crystal in preparation of the manuscript. The comments of Dr. Joao Pedro de Magalhães and of anonymous referees were extremely helpful for improving the paper.
PY - 2009/1/1
Y1 - 2009/1/1
N2 - An association between aging/longevity and cancer has long been suggested, yet the evolutionary and molecular links between these complicated traits remain elusive. Here, we analyze the relationship between longevity- and cancer-associated genes/proteins (LAGs/LAPs and CAGs/CAPs, respectively). Specifically, we address the following questions: (1) to what extent the CAGs and LAGs are evolutionary conserved and how they (or their orthologs) are related to each other in diverse species? (2) Could they act in cooperative manner at a protein level via protein-protein interactions (PPIs) and, if so, by forming a PPI network? We found that (i) the common genes (both LAGs and CAGs) show the same remarkable trend from yeast to humans: tumor suppressors are associated with lifespan extension, whereas the oncogenes are associated with reduced lifespan; (ii) LAPs and CAPs have a significantly higher average connectivity than other proteins in the human interactome; and (iii) LAPs and CAPs may act in cooperative manner via numerous direct and indirect PPIs between themselves and eventually by forming a PPI network. Altogether, the results of this study provide strong evidence for the existence of evolutionary and molecular links between longevity and cancer.
AB - An association between aging/longevity and cancer has long been suggested, yet the evolutionary and molecular links between these complicated traits remain elusive. Here, we analyze the relationship between longevity- and cancer-associated genes/proteins (LAGs/LAPs and CAGs/CAPs, respectively). Specifically, we address the following questions: (1) to what extent the CAGs and LAGs are evolutionary conserved and how they (or their orthologs) are related to each other in diverse species? (2) Could they act in cooperative manner at a protein level via protein-protein interactions (PPIs) and, if so, by forming a PPI network? We found that (i) the common genes (both LAGs and CAGs) show the same remarkable trend from yeast to humans: tumor suppressors are associated with lifespan extension, whereas the oncogenes are associated with reduced lifespan; (ii) LAPs and CAPs have a significantly higher average connectivity than other proteins in the human interactome; and (iii) LAPs and CAPs may act in cooperative manner via numerous direct and indirect PPIs between themselves and eventually by forming a PPI network. Altogether, the results of this study provide strong evidence for the existence of evolutionary and molecular links between longevity and cancer.
KW - Cancer genes
KW - Evolutionary conservation
KW - Longevity genes
KW - PPI networks
KW - Protein-protein interactions (PPIs)
UR - http://www.scopus.com/inward/record.url?scp=58149330989&partnerID=8YFLogxK
U2 - 10.1016/j.mad.2008.04.002
DO - 10.1016/j.mad.2008.04.002
M3 - Article
AN - SCOPUS:58149330989
SN - 0047-6374
VL - 130
SP - 33
EP - 39
JO - Mechanisms of Ageing and Development
JF - Mechanisms of Ageing and Development
IS - 1-2
ER -
