Comorbidities and Malignancy among NAFLD Patients Compared to the General Population, A Nation-Based Study

Naim Abu-Freha, Bracha Cohen, Michal Gordon, Sarah Weissmann, Alexander Fich, Daniela Munteanu, David Yardeni, Ohad Etzion

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

(1) Background: Non-alcoholic fatty liver disease (NAFLD) is a common liver disease. Aims: We aimed to investigate the frequency of comorbidities and malignancies among NAFLD patients compared to the general population. (2) Methods: A retrospective study included adult patients with a NAFLD diagnosis. A control group was matched for age and gender. Demographics, comorbidities, malignancies, and mortality were collected and compared. (3) Results: 211,955 NAFLD patients were analyzed in comparison to 452,012 matched general population controls. Significantly higher rates of diabetes mellitus (23.2% vs. 13.3%), obesity (58.8% vs. 27.8%), hypertension (57.2% vs. 39.9%), chronic ischemic heart disease (24.7% vs. 17.3%), and CVA (3.2% vs. 2.8%) were found among NAFLD patients. Patients with NAFLD had significantly higher rates of the following malignancies: prostate cancer (1.6% vs. 1.2%), breast cancer (2.6% vs. 1.9%), colorectal cancer (1.8% vs. 1.4%), uterine cancer (0.4 vs. 0.2%), kidney cancer (0.8% vs. 0.5%), but a lower rate of lung cancer (0.9% vs. 1.2%) and stomach cancer (0.3% vs. 0.4%). The all-cause mortality rate among NAFLD patients was significantly lower in comparison to the general population (10.8% vs. 14.7%, p < 0.001). (4) Conclusions: Higher rates of comorbidities and malignancies among NAFLD patients were observed, but a lower rate of all-cause mortality was found.

Original languageEnglish
Article number1110
JournalBiomedicines
Volume11
Issue number4
DOIs
StatePublished - 1 Apr 2023

Keywords

  • Israel
  • comorbidities
  • fatty liver
  • malignancy
  • mortality

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology
  • Medicine (miscellaneous)

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