Comorbidities and Risk Factors of Patients Diagnosed with CRC after Positive Fecal Test in Real Life

Naim Abu-Freha, Rachel Gouldner, Bracha Cohen, Michal Gordon, Orly Sagi, Gadeer Taha, Liza Ben Shoshan, Zohar Levi

    Research output: Contribution to journalArticlepeer-review

    Abstract

    (1) Background: Fecal occult blood test (FOBT) is the modality of choice in most countries for colorectal cancer (CRC) screening. We aimed to investigate the risk factors for CRC among patients with a positive FOBT in real life. (2) Methods: This was a retrospective study that included patients who tested positive for FOBT. Data regarding the comorbidities and laboratories were collected and compared between CRC and non-CRC groups. (3) Results: Positive FOBT was found among 45,500 (5.36%) subjects and CRC was found in 1502 (3.3%). CRC patients were older, age 62.7 ± 7.15 years compared with 59.33 ± 7.3 years (p < 0.001), and had significantly higher rates of hypertension (48.4% vs. 44.7%, p = 0.002), iron-deficiency anemia (20.6% vs. 16.4, p < 0.001), family history of CRC (7.3% vs. 5.1%, p < 0.001), and previous CRC (6.5% vs. 0.3%, p < 0.001). Lower levels of hemoglobin, iron, and ferritin were found in the CRC group. Age, family history of CRC, and previous CRC were found to be significant risk factors for diagnosis of CRC after positive FOBT with OR of 1.057, 1.4, and 15.9, respectively. (4) Conclusions: Iron-deficiency anemia, family history of CRC, previous colorectal cancer, and low hemoglobin, iron, and ferritin levels should direct physicians to give high priority to colonoscopy scheduling.

    Original languageEnglish
    Article number5557
    JournalCancers
    Volume14
    Issue number22
    DOIs
    StatePublished - 1 Nov 2022

    Keywords

    • colorectal cancer
    • fecal testing
    • risk factor
    • screening

    ASJC Scopus subject areas

    • Oncology
    • Cancer Research

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