Comorbidities in adolescents with inflammatory bowel disease: findings from a population-based cohort study

Itai Ghersin, Neron Khateeb, Lior H. Katz, Saleh Daher, Raanan Shamir, Amit Assa

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Background: Inflammatory bowel diseases are associated with various immune- and non-immune-mediated conditions. We aimed to assess the association of inflammatory bowel diseases with comorbidities at late adolescence. Methods: Jewish Israeli adolescents who underwent a general health evaluation prior to enlistment to the Israeli Defense Forces from 2002 to 2016 were included. Results: Overall, 891 subjects (595 Crohn’s disease, 296 ulcerative colitis, median age 17.1 years) and 1,141,841 controls were analyzed. Crohn’s disease was associated with arthritis (odds ratio (OR) 4.7, 95% confidence interval (CI) 2.4–9.1), thyroid disease (OR 2.6, 95% CI 1.2–5.5), atopic dermatitis (OR 2, 95% CI 1.1–3.6), autoimmune hepatitis (OR 4.4, 95% CI 2.3–8.6), nephrolithiasis (OR 3.6, 95% CI 1.2–11.4), and pancreatitis (OR 41.8, 95% CI 17.2–101.9). Ulcerative colitis was associated with arthritis (OR 3.6, 95% CI 1.0–9.8), thyroid disease (OR 4.8, 95% CI 1.2–19.4), autoimmune hepatitis (OR 8, 95% CI 4–16.2), and pancreatitis (OR 51, 95% CI 16.1–158.9). Primary sclerosing cholangitis was associated with both diseases. Asthma, celiac, type 1 diabetes, psoriasis, and bone fractures were not more common in both diseases. Male predominance was noted for most associations. Conclusions: At adolescence, both Crohn’s disease and ulcerative colitis are associated with multiple comorbidities, not limited to autoimmune disorders.

Original languageEnglish
Pages (from-to)1256-1262
Number of pages7
JournalPediatric Research
Issue number7
StatePublished - 1 Jun 2020
Externally publishedYes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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