Comorbidity of gout and rheumatoid arthritis in a large population database

Rona Merdler-Rabinowicz, Shmuel Tiosano, Doron Comaneshter, Arnon D. Cohen, Howard Amital

    Research output: Contribution to journalArticlepeer-review

    21 Scopus citations


    Coexistence of rheumatoid arthritis and gout is considered to be unusual. The current study was designed as a population-based cross-sectional study, utilizing the medical database of Clalit Health Services, the largest healthcare provider organization in Israel. Data of adult patients who were previously diagnosed with rheumatoid arthritis was retrieved. For each patient, five age- and sex-matched control patients were randomly selected. Different parameters including BMI, socioeconomic status, and existence of gout as well as smoking and hypertension were examined for both groups. The study included 11,540 patients with rheumatoid arthritis and 56,763 controls. The proportion of gout in the study group was high compared to controls (1.61 vs. 0.92%, P < 0.001). In a multivariate analysis, rheumatoid arthritis was associated with gout (OR = 1.72, 95% CI 1.45–2.05, P = 0.00). The proportion of gout in rheumatoid arthritis patients is not lower than in the general population.

    Original languageEnglish
    Pages (from-to)657-660
    Number of pages4
    JournalClinical Rheumatology
    Issue number3
    StatePublished - 1 Mar 2017


    • Comorbidity
    • Crystal induced arthritis
    • Gout
    • Inflammation
    • Rheumatic diseases
    • Rheumatoid arthritis

    ASJC Scopus subject areas

    • Rheumatology


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